Endocrine disruptor hexachlorobenzene induces cell migration and invasion, and enhances aromatase expression levels in human endometrial stromal cells

• Published in: Food and chemical toxicology Vol. 162; p. 112867
• Main Authors: Chiappini, Florencia, Ceballos, Leandro, Olivares, Carla, Bastón, Juan Ignacio, Miret, Noelia, Pontillo, Carolina, Zárate, Lorena, Singla, José Javier, Farina, Mariana, Meresman, Gabriela, Randi, Andrea
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2022
• Subjects: aromatase; Aryl hydrocarbon receptor; aryl hydrocarbon receptors; Cell invasion; Cell migration; cell movement; chlorinated hydrocarbons; endocrine-disrupting chemicals; Endometriosis; endometrium; estrogen receptors; hexachlorobenzene; humans; ligands; metalloproteinases; Oestrogen receptor; Organochlorine pesticide; phosphorylation; progesterone receptors; prostaglandin synthase; rats; risk factors; toxicology; human endometrial stromal cells; cyclooxygenase-2; metalloproteinases; oestradiol; Endometriosis; 4,7-orthophenanthroline; tyrosine 537; endometrial stromal cells from eutopic endometria of control subjects; progesterone receptor; Oestrogen receptor; Aryl hydrocarbon receptor; 4-Amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazolo [3,4-d]pyrimidine; α-naphthoflavone; Cell invasion; Organochlorine pesticide; Hexachlorobenzene; Cell migration

Endometriosis is the presence and growth of endometrial tissue outside of the uterus. Previous studies have suggested that endocrine disrupting chemicals such as organochlorine pesticides could be a risk factor for endometriosis. Hexachlorobenzene (HCB) is a weak ligand of the aryl hydrocarbon recep...