Tolerance with low dose intravenous nitroglycerin therapy in acute myocardial infarction

• Published in: The American journal of cardiology Vol. 64; no. 10; pp. 581 - 587
• Main Authors: Jugdutt, Bodh I., Warnica, J.Wayne
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.09.1989; Elsevier
• Subjects: Antianginal agents. Coronary vasodilator agents; Biological and medical sciences; Blood Pressure - drug effects; Cardiovascular system; Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; Female; Humans; Infusions, Intravenous; Male; Medical sciences; Middle Aged; Myocardial Infarction - drug therapy; Nitroglycerin - administration & dosage; Nitroglycerin - therapeutic use; Pharmacology. Drug treatments; Random Allocation; Time Factors; Antianginal agent; Human; Intravenous administration; Infarct; Acute; Low dose; Tolerance; Cardiovascular disease; Coronary heart disease; Long term; Chemotherapy; Treatment; Organic nitrate; Myocardium; Hemodynamics

The question of vascular tolerance was examined in 154 patients with acute myocardial infarction (64 anterior, 90 inferior) who were treated with prolonged low dose intravenous nitroglycerin in a recent randomized placebo-controlled study. The dose of nitroglycerin was carefully titrated to decrease...