What tau distribution maximizes fast axonal transport toward the axonal synapse?

• Published in: Mathematical biosciences Vol. 253; pp. 19 - 24
• Main Authors: Kuznetsov, I.A., Kuznetsov, A.V.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2014
• Subjects: Alzheimer’s disease; Axonal Transport - physiology; Axons - metabolism; Humans; Kinesin - metabolism; Mathematical Concepts; Microtubules - metabolism; Models, Neurological; Optimal control; Organelle transport; Synapses - metabolism; Tau protein; tau Proteins - metabolism; Tau protein; Alzheimer’s disease; Optimal control; Organelle transport

•We developed a model describing the effect of tau protein distribution on fast axonal transport.•We investigated the effect of various tau distributions along the axon length on organelle flux toward the axon synapse.•We computed what tau distribution would give the largest organelle flux toward th...