A Functional Genomic Approach Identifies FAL1 as an Oncogenic Long Noncoding RNA that Associates with BMI1 and Represses p21 Expression in Cancer

• Published in: Cancer cell Vol. 26; no. 3; pp. 344 - 357
• Main Authors: Hu, Xiaowen, Feng, Yi, Zhang, Dongmei, Zhao, Sihai D., Hu, Zhongyi, Greshock, Joel, Zhang, Youyou, Yang, Lu, Zhong, Xiaomin, Wang, Li-Ping, Jean, Stephanie, Li, Chunsheng, Huang, Qihong, Katsaros, Dionyssios, Montone, Kathleen T., Tanyi, Janos L., Lu, Yiling, Boyd, Jeff, Nathanson, Katherine L., Li, Hongzhe, Mills, Gordon B., Zhang, Lin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 08.09.2014
• Subjects: Animals; Cell Line, Tumor; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Genomics; Humans; Kaplan-Meier Estimate; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Glandular and Epithelial - genetics; Neoplasms, Glandular and Epithelial - metabolism; Neoplasms, Glandular and Epithelial - mortality; Neoplasms, Glandular and Epithelial - pathology; Oncogenes; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - mortality; Ovarian Neoplasms - pathology; Polycomb Repressive Complex 1 - metabolism; Polymorphism, Single Nucleotide; Protein Stability; RNA Interference; RNA, Long Noncoding - physiology; Transcriptome; Tumor Burden

In a genome-wide survey on somatic copy-number alterations (SCNAs) of long noncoding RNA (lncRNA) in 2,394 tumor specimens from 12 cancer types, we found that about 21.8% of lncRNA genes were located in regions with focal SCNAs. By integrating bioinformatics analyses of lncRNA SCNAs and expression w...