Effects of graded intravenous doses of fructose on glycogen synthase in the liver of fasted rats

• Published in: Metabolism, clinical and experimental Vol. 36; no. 4; p. 338
• Main Authors: Niewoehner, C B, Nuttall, B Q, Nuttall, F Q
• Format: Journal Article
• Language: English
• Published: United States 01.04.1987
• Subjects: Animals; Fasting; Fructose - administration & dosage; Glucose-6-Phosphate; Glucosephosphates - metabolism; Glycogen Synthase - metabolism; Injections, Intravenous; Liver - enzymology; Liver - metabolism; Male; Phosphorylase a - metabolism; Rats; Rats, Inbred Strains

We have examined in fasted rats the effects of graded doses of intravenous fructose (50 to 500 mg/kg) in order to determine potential mechanisms by which different concentrations of fructose reaching the liver may modify the activity of glycogen synthase (and phosphorylase). With increasing fructose...