Drug―Gene Modeling in Pediatric T-Cell Acute Lymphoblastic Leukemia Highlights Importance of 6-Mercaptopurine for Outcome

• Published in: Cancer research (Chicago, Ill.) Vol. 73; no. 9; pp. 2749 - 2759
• Main Authors: BEESLEY, Alex H, FIRTH, Martin J, ANDERSON, Denise, SAMUELS, Amy L, FORD, Jette, KEES, Ursula R
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.05.2013
• Subjects: Antineoplastic agents; Biological and medical sciences; Cell Line, Tumor; Child; Cohort Studies; Drug Resistance, Neoplasm - genetics; Drug Screening Assays, Antitumor; Follow-Up Studies; Gene Expression Profiling; Genetic Therapy - methods; Hematologic and hematopoietic diseases; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; Mercaptopurine - therapeutic use; Models, Statistical; Multidrug Resistance-Associated Proteins - metabolism; Oligonucleotide Array Sequence Analysis; Pharmacogenetics; Pharmacology. Drug treatments; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Remission Induction; Sulfite Oxidase - metabolism; Treatment Outcome; Tumors; Human; Antineoplastic agent; Drug; Pediatrics; Purine derivatives; Prognosis; Thiopurine derivatives; Malignant hemopathy; Modeling; Antimetabolic; Gene; Lymphoproliferative syndrome; Genetics; Child; Cancer; Mercaptopurine; T cell acute lymphoblastic leukemia

Patients relapsing with T-cell acute lymphoblastic leukemia (T-ALL) face a dismal outcome. The aim of this study was to identify new markers of drug resistance and clinical response in T-ALL. We measured gene expression and drug sensitivity in 15 pediatric T-ALL cell lines to find signatures predict...