Apoptosis induced by retinoic acid in Hep 3B cells in vitro

• Published in: Cancer letters Vol. 107; no. 1; pp. 149 - 159
• Main Authors: Kim, Dae Ghon, Jo, Baik Hwan, You, Kyung Ran, Ahn, Deuk Soo
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.10.1996; Elsevier
• Subjects: Antineoplastic agents; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Apoptosis - genetics; Biological and medical sciences; Carcinoma, Hepatocellular - pathology; Cell Cycle - drug effects; Cycloheximide - pharmacology; DNA, Neoplasm - analysis; General aspects; Hep 3B cells; Hepatom; Humans; Liver Neoplasms - pathology; Medical sciences; Microscopy, Electron; Pharmacology. Drug treatments; Protein Synthesis Inhibitors - pharmacology; Retinoic acid; Tretinoin - pharmacology; Hep 3B cells; Retinoic acid; Hepatom; Apoptosis; Antineoplastic agent; Human; Hepatic disease; Malignant tumor; Retinoids; In vitro; Liver cell carcinoma; Cell death; Established cell line; Digestive diseases; Tumor cell

Human hepatoma Hep 3B cells underwent apoptosis in response to 100 μM all-trans retinoic acid (RA) in full serum (10% fetal calf serum) condition in vitro. Cell death began approximately 24 h following treatment, with more than 80% of the cells dead after 60 h. The dead cells, mainly detached cells,...