Polygonatum sibiricum polysaccharide prevents depression-like behaviors by reducing oxidative stress, inflammation, and cellular and synaptic damage

• Published in: Journal of ethnopharmacology Vol. 275; p. 114164
• Main Authors: Shen, Fengming, Song, Zhujin, Xie, Pan, Li, Lei, Wang, Bin, Peng, Daiyin, Zhu, Guoqi
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 15.07.2021
• Subjects: Animals; Astrocytes - drug effects; Behavior, Animal - drug effects; blood serum; brain; caspase-3; Cortisol; cytokines; Cytokines - metabolism; Depression; Depression - drug therapy; Depression - etiology; Depression - metabolism; Disease Models, Animal; fluorescent antibody technique; Fourier transform infrared spectroscopy; Hippocampus - drug effects; histopathology; Hydrocortisone - blood; Hypothalamo-Hypophyseal System - drug effects; Inflammation; Inflammation - metabolism; lipopolysaccharides; Lipopolysaccharides - toxicity; Male; mammals; mechanism of action; Mice; Mice, Inbred C57BL; mitogen-activated protein kinase; neurons; non-specific serine/threonine protein kinase; Oriental traditional medicine; Oxidative stress; Oxidative Stress - drug effects; pathogenesis; phosphorylation; Polygonatum - chemistry; Polygonatum sibiricum; Polygonatum sibiricum polysaccharide; Polysaccharides - chemistry; Polysaccharides - pharmacology; Polysaccharides - therapeutic use; protein synthesis; rapamycin; serotonin; Serotonin - metabolism; Stress, Psychological - complications; Synapses - drug effects; Synaptic disorders; transmission electron microscopy; Oxidative stress; Synaptic disorders; CUMS; Depression; FT-IR; Cortisol; Inflammation; Polygonatum sibiricum polysaccharide; MDD; PSP; TST; SPT; HPA

According to traditional Chinese medicine (TCM) theory (Yi Xue Zheng Zhuan), the main factors associated with the pathogenesis of depression are deficiencies relating to five zang organs, Qi, and blood. Polygonatum sibiricum F. Delaroche (PS), which may avert these pathological changes, has been use...