Polygonatum sibiricum polysaccharide prevents depression-like behaviors by reducing oxidative stress, inflammation, and cellular and synaptic damage - Shen, Fengming; Song, Zhujin; Xie, Pan; Li, Lei; Wang, Bin; Peng, Daiyin; Zhu, Guoqi (Journal of ethnopharmacology, 2021)
Keywords: Animals; Astrocytes - drug effects; Behavior, Animal - drug effects; blood serum; brain; caspase-3; Cortisol; cytokines; Cytokines - metabolism; Depression; Depression - drug therapy; Depression - etiology; Depression - metabolism; Disease Models, Animal; fluorescent antibody technique; Fourier transform infrared spectroscopy; Hippocampus - drug effects; histopathology; Hydrocortisone - blood; Hypothalamo-Hypophyseal System - drug effects; Inflammation; Inflammation - metabolism; lipopolysaccharides; Lipopolysaccharides - toxicity; Male; mammals; mechanism of action; Mice; Mice, Inbred C57BL; mitogen-activated protein kinase; neurons; non-specific serine/threonine protein kinase; Oriental traditional medicine; Oxidative stress; Oxidative Stress - drug effects; pathogenesis; phosphorylation; Polygonatum - chemistry; Polygonatum sibiricum; Polygonatum sibiricum polysaccharide; Polysaccharides - chemistry; Polysaccharides - pharmacology; Polysaccharides - therapeutic use; protein synthesis; rapamycin; serotonin; Serotonin - metabolism; Stress, Psychological - complications; Synapses - drug effects; Synaptic disorders; transmission electron microscopy; Oxidative stress; Synaptic disorders; CUMS; Depression; FT-IR; Cortisol; Inflammation; Polygonatum sibiricum polysaccharide; MDD; PSP; TST; SPT; HPA