Sensitivity to immunodepressant action of cyclophosphamide: analysis of interstrain differences in mice

• Published in: International journal of immunopharmacology Vol. 7; no. 6; p. 875
• Main Authors: Pevnitsky, L A, Telegin LYu, Zhirnov, G F, Mazurov, A V, Viktorov, V V
• Format: Journal Article
• Language: English
• Published: England 1985
• Subjects: Animals; Biotransformation; Cyclophosphamide - metabolism; Cyclophosphamide - pharmacology; Immune Tolerance - drug effects; In Vitro Techniques; Kinetics; Male; Mice; Mice, Inbred Strains; Microsomes, Liver - metabolism; Species Specificity

In one of our previous studies (Pevnitsky et al., Bull. exp. Biol. Med., 83, 438-440, 1977), we have found significant differences between various strains of mice in the sensitivity to immunodepressant action of cyclophosphamide (CP). The degree of these differences was not determined by the level o...