Radiosynthesis, rodent biodistribution, and metabolism of 1-deoxy-1-[ 18F]fluoro- d-fructose

• Published in: Nuclear medicine and biology Vol. 22; no. 6; pp. 719 - 725
• Main Authors: Haradahira, Terushi, Tanaka, Akihiro, Maeda, Minoru, Kanazawa, Yoko, Ichiya, Yu-Ichi, Masuda, Kouji
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.08.1995; Elsevier
• Subjects: Animals; Biological and medical sciences; Biotransformation; Brain - metabolism; Contrast media. Radiopharmaceuticals; Fibrosarcoma - metabolism; Fluorine Radioisotopes; Fructose - analogs & derivatives; Fructose - chemical synthesis; Fructose - metabolism; Fructose - pharmacokinetics; Indicators and Reagents; Isotope Labeling - methods; Kinetics; Magnetic Resonance Spectroscopy; Male; Medical sciences; Mice; Pharmacology. Drug treatments; Radioisotope Dilution Technique; Rats; Rats, Wistar; Time Factors; Tissue Distribution; In vivo; Radiolabelling; Fluorine; Radioactive tracers; Bioavailability; Metabolism; Pharmacokinetics; Chemical synthesis; Fructose; Radioactivity

Fluorine-18 labeled analog of d-fructose, 1-deoxy-1-[ 18F]fluoro- d-fructose (1-[ 18F]FDFrc), was synthesized by nucleophilic substitution of [ 18F]fluoride ion and the effect of the fluorine substitution on its in vivo metabolism was investigated. The tissue distributions of 1-[ 18F]FDFrc in rats a...