Interferon antibodies in patients with chronic HBV infection treated with recombinant interferon

• Published in: Journal of hepatology Vol. 8; no. 3; pp. 351 - 357
• Main Authors: Porres, Juan Carlos, Carreño, Vicente, Ruíz, Mercedes, Marrón, JoséAntonio, Bartolomé, Javier
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier B.V 01.05.1989; Elsevier
• Subjects: Adolescent; Adult; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antibodies - analysis; Antiviral agents; Biological and medical sciences; Child; Child, Preschool; Chronic Disease; DNA, Viral - analysis; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Hepatitis B - immunology; Hepatitis B - therapy; Hepatitis B e Antigens - analysis; Humans; Interferon Type I - immunology; Interferon Type I - therapeutic use; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Radioimmunoassay; Recombinant Proteins; Human; Antibody; Liver; Infection; Viral hepatitis B; Chemotherapy; Chronic; Viral disease; Adult; Digestive diseases; Complication; Interferon; Recombinant protein; Child

In different trials, a total of 46 adults and 12 children suffering from chronic hepatitis B virus (HBV) and who were HBV-DNA- and HBeAg-positive were treated with recombinant interferon-α (rIFNα)-2A. The interferon was administered intramuscularly in different doses ranging from 1.5 MU to 20 MU/m 2...