Comparison of Stress Hormone Response, Interleukin-6 and Anaesthetic Characteristics of Two Anaesthetic Techniques: Volatile Induction and Maintenance of Anaesthesia using Sevoflurane versus Total Intravenous Anaesthesia using Propofol and Remifentanil
This prospective randomized study compared the effects of two types of anaesthesia on peri-operative anaesthetic profiles from induction to recovery and on immunological and neurohormonal responses to anaesthesia and surgical stress. Forty patients were assigned to undergo either volatile induction...
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Published in | Journal of international medical research Vol. 37; no. 6; pp. 1760 - 1771 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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London, England
SAGE Publications
01.11.2009
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Abstract | This prospective randomized study compared the effects of two types of anaesthesia on peri-operative anaesthetic profiles from induction to recovery and on immunological and neurohormonal responses to anaesthesia and surgical stress. Forty patients were assigned to undergo either volatile induction and maintenance of anaesthesia (VIMA) with sevoflurane or total intravenous anaesthesia (TIVA) with propofol and remifentanil. Plasma adrenaline, noradrenaline, cortisol, glucose and interleukin-6 (IL-6) levels were measured at baseline, induction, incision and extubation. TIVA produced a significantly lower intubation score, shorter time to intubation and faster waking time than VIMA, but recovery profiles did not differ. Adrenaline, noradrenaline, cortisol and glucose levels were significantly lower with TIVA than VIMA, but there was no difference in IL-6 levels between the two groups. TIVA with propofol and remifentanil may be preferable to VIMA with sevoflurane alone because it leads to smoother, more rapid induction, more rapid awakening and lower stress responses to surgical stimuli. |
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AbstractList | This prospective randomized study compared the effects of two types of anaesthesia on peri-operative anaesthetic profiles from induction to recovery and on immunological and neurohormonal responses to anaesthesia and surgical stress. Forty patients were assigned to undergo either volatile induction and maintenance of anaesthesia (VIMA) with sevoflurane or total intravenous anaesthesia (TIVA) with propofol and remifentanil. Plasma adrenaline, noradrenaline, cortisol, glucose and interleukin-6 (IL-6) levels were measured at baseline, induction, incision and extubation. TIVA produced a significantly lower intubation score, shorter time to intubation and faster waking time than VIMA, but recovery profiles did not differ. Adrenaline, noradrenaline, cortisol and glucose levels were significantly lower with TIVA than VIMA, but there was no difference in IL-6 levels between the two groups. TIVA with propofol and remifentanil may be preferable to VIMA with sevoflurane alone because it leads to smoother, more rapid induction, more rapid awakening and lower stress responses to surgical stimuli. |
Author | Jeon, YS Kim, DW Jung, HS Ihn, CH Kim, YS Choi, JW Joo, JD Kwon, SY |
Author_xml | – sequence: 1 givenname: CH surname: Ihn fullname: Ihn, CH – sequence: 2 givenname: JD surname: Joo fullname: Joo, JD – sequence: 3 givenname: JW surname: Choi fullname: Choi, JW – sequence: 4 givenname: DW surname: Kim fullname: Kim, DW – sequence: 5 givenname: YS surname: Jeon fullname: Jeon, YS – sequence: 6 givenname: YS surname: Kim fullname: Kim, YS – sequence: 7 givenname: HS surname: Jung fullname: Jung, HS – sequence: 8 givenname: SY surname: Kwon fullname: Kwon, SY |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20146874$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Adolescent Adult Aged Anesthesia, Inhalation - methods Anesthesia, Intravenous - methods Anesthetics, Inhalation - pharmacology Anesthetics, Intravenous - pharmacology Blood Glucose - drug effects Blood Loss, Surgical Demography Female Hemodynamics - drug effects Hormones - blood Humans Hysterectomy Interleukin-6 - blood Methyl Ethers - pharmacology Middle Aged Piperidines - pharmacology Propofol - pharmacology Stress, Physiological - drug effects Volatilization Young Adult |
Title | Comparison of Stress Hormone Response, Interleukin-6 and Anaesthetic Characteristics of Two Anaesthetic Techniques: Volatile Induction and Maintenance of Anaesthesia using Sevoflurane versus Total Intravenous Anaesthesia using Propofol and Remifentanil |
URI | https://journals.sagepub.com/doi/full/10.1177/147323000903700612 https://www.ncbi.nlm.nih.gov/pubmed/20146874 https://search.proquest.com/docview/733683424 |
Volume | 37 |
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