Developing a Raman spectroscopy-based tool to stratify patient response to pre-operative radiotherapy in rectal cancer

• Published in: Analyst (London) Vol. 146; no. 2; pp. 581 - 589
• Main Authors: Kirkby, Chloe J, Gala de Pablo, Julia, Tinkler-Hundal, Emma, Wood, Henry M, Evans, Stephen D, West, Nicholas P
• Format: Journal Article
• Language: English
• Published: England 21.01.2021
• Subjects: Aged; Biopsy; Female; Humans; Male; Middle Aged; Paraffin Embedding; Preoperative Period; Rectal Neoplasms - pathology; Rectal Neoplasms - radiotherapy; Rectal Neoplasms - surgery; Spectrum Analysis, Raman - methods; Tissue Fixation; Treatment Outcome

Rectal cancer patients frequently receive pre-operative radiotherapy (RT), prior to surgical resection. However, colorectal cancer is heterogeneous and the degree of tumour response to pre-operative RT is highly variable. There are currently no clinically approved methods of predicting response to R...