Bulk-freezing of Theileria parva stabilates for vaccine production

The freezing and thawing characteristics of different volume samples of freezing medium and Theileria parva stabilates were studied in order to identify suitable conditions for freezing large volumes of stabilates for use in the preparation of vaccines. Conventionally, 1.8 ml aliquots are used but a...

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Published inInternational journal for parasitology Vol. 26; no. 1; pp. 67 - 70
Main Authors Njuguna, L.M., Musisi, F.L.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 1996
Elsevier Science
Subjects
Animal protozoal diseases
Animals
Antibodies, Protozoan - blood
Biological and medical sciences
bulk-freezing
Cattle
Freezing
freezing medium
Infectious diseases
Medical sciences
Parasitic diseases
Protozoal diseases
Protozoan Vaccines - immunology
Rabbits
stabilates
Theileria parva
Theileria parva - immunology
Theileriasis - prevention & control
Ticks - parasitology
Vaccination
vaccine production
vaccine production
bulk-freezing
freezing medium
Theileria parva
stabilates
Theileriosis
Protozoa
Protozoal disease
Parasite
Vaccine
Parasitosis
Freezing
Infection
Immunogenicity
Pathogenic
Infectivity
Livestock
Sporozoa
Viability
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Abstract The freezing and thawing characteristics of different volume samples of freezing medium and Theileria parva stabilates were studied in order to identify suitable conditions for freezing large volumes of stabilates for use in the preparation of vaccines. Conventionally, 1.8 ml aliquots are used but are cumbersome to handle in the field preparation of trivalent vaccines. In this study, 75 ml aliquots of the stabilates were found to exhibit freezing and thawing characteristics similar to those of the 1.8 ml aliquots. Bulk freezing of 2 stabilates yielded sporozoites which remained infective for cattle upon thawing, induced a range of clinical reactions in vaccinated cattle and stimulated the development of immune reactions.
AbstractList The freezing and thawing characteristics of different volume samples of freezing medium and Theileria parva stabilates were studied in order to identify suitable conditions for freezing large volumes of stabilates for use in the preparation of vaccines. Conventionally, 1.8 ml aliquots are used but are cumbersome to handle in the field preparation of trivalent vaccines. In this study, 75 ml aliquots of the stabilates were found to exhibit freezing and thawing characteristics similar to those of the 1.8 ml aliquots. Bulk freezing of 2 stabilates yielded sporozoites which remained infective for cattle upon thawing, induced a range of clinical reactions in vaccinated cattle and stimulated the development of immune reactions.
The freezing and thawing characteristics of different volume samples of freezing medium and Theileria parva stabilates were studied in order to identify suitable conditions for freezing large volumes of stabilates for use in the preparation of vaccines. Conventionally, 1.8 ml aliquots are used but are cumbersome to handle in the field preparation of trivalent vaccines. In this study, 75 ml aliquots of the stabilates were found to exhibit freezing and thawing characteristics similar to those of the 1.8 ml aliquots. Bulk freezing of 2 stabilates yielded sporozoites which remained infective for cattle upon thawing, induced a range of clinical reactions in vaccinated cattle and stimulated the development of immune reactions.
Author Njuguna, L.M.
Musisi, F.L.
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10.1016/S0007-1935(17)35894-3
10.1016/S0034-5288(18)33992-4
10.1038/2051032a0
10.1016/0014-4894(58)90020-1
10.1017/S0031182000029036
10.1016/0020-7519(73)90082-9
10.1007/BF02239682
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Issue 1
Keywords vaccine production
bulk-freezing
freezing medium
Theileria parva
stabilates
Theileriosis
Protozoa
Protozoal disease
Parasite
Vaccine
Parasitosis
Freezing
Infection
Immunogenicity
Pathogenic
Infectivity
Livestock
Sporozoa
Viability
Language English
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SubjectTerms Animal protozoal diseases
Animals
Antibodies, Protozoan - blood
Biological and medical sciences
bulk-freezing
Cattle
Freezing
freezing medium
Infectious diseases
Medical sciences
Parasitic diseases
Protozoal diseases
Protozoan Vaccines - immunology
Rabbits
stabilates
Theileria parva
Theileria parva - immunology
Theileriasis - prevention & control
Ticks - parasitology
Vaccination
vaccine production
Title Bulk-freezing of Theileria parva stabilates for vaccine production
URI https://dx.doi.org/10.1016/0020-7519(95)00102-6
https://www.ncbi.nlm.nih.gov/pubmed/9198598
https://search.proquest.com/docview/78023714
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