Protective effect of oral cysteamine against induction of gastric cancer by N-methyl- N′-nitro- N-nitrosoguanidine in Wistar rats

• Published in: European journal of cancer & clinical oncology Vol. 25; no. 1; pp. 91 - 97
• Main Authors: Tatsuta, Masaharu, Iishi, Hiroyasu, Yamamura, Hisako, Baba, Miyako, Mikoni, Tomiko, Taniguchi, Haruo
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 1989; New York, NY Pergamon Press
• Subjects: Adenocarcinoma - chemically induced; Adenocarcinoma - pathology; Adenocarcinoma - prevention & control; Animals; Biological and medical sciences; Carcinogenesis, carcinogens and anticarcinogens; Chemical agents; Cysteamine - therapeutic use; Gastric Mucosa - pathology; Gastrins - blood; Hydrogen-Ion Concentration; Male; Medical sciences; Methylnitronitrosoguanidine; Mitosis - drug effects; Rats; Rats, Inbred Strains; Stomach Neoplasms - chemically induced; Stomach Neoplasms - pathology; Stomach Neoplasms - prevention & control; Tumors; Stomach; Rat; Interaction; Nitrosamine; Rodentia; Tumorigenicity; Anticarcinogen; Pathology; Carcinogen; Vertebrata; Mammalia; Animal; Digestive diseases; Frequency; Experimental tumor

The effect of oral administration of cysteamine ( 2-aminoethanethiol hydrochloride) on the incidence and histology of gastric adenocarcinomas induced by N-methyl- N′-nitro- N-nitrosoguanidine (MNNG) was investigated in inbred Wistar rats. Oral administration of 0.4% cysteamine in food after treatmen...