Protection against 7,12-dimethylbenzanthracene-induced tumour initiation by protein A in mouse skin

• Published in: Cancer letters Vol. 61; no. 2; pp. 105 - 110
• Main Authors: Kumar, Sushil, Shukla, Yogeshwer, Prasad, Arun Kumar, Verma, A.S., Dwivedi, P.D., Mehrotra, N.K., Ray, P.K.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 10.01.1992; Elsevier
• Subjects: 7,12-dimethylbenzanthracene; 9,10-Dimethyl-1,2-benzanthracene; Animal tumors. Experimental tumors; Animals; Antineoplastic Agents; Biological and medical sciences; Experimental skin tumors; Female; Medical sciences; Mice; mouse skin; protein A; Skin Neoplasms - chemically induced; Skin Neoplasms - prevention & control; Staphylococcal Protein A - administration & dosage; Survival Analysis; Tumors; tumour initiation; tumour initiation; mouse skin; protein A; 7,12-dimethylbenzanthracene; Skin disease; Intraperitoneal administration; Rodentia; Tumor initiation; Glycoproteins; Anticarcinogen; Multiple dose; Prevention; Vertebrata; Experimental disease; Mammalia; Mouse; Animal; Bacteria; Micrococcales; Tumor; Micrococcaceae; Staphylococcus aureus

Protein A is an immunostimulating glycoprotein obtained from Staphylococcus aureus Cowan I. Its antitumour activity is proven in various tumour models. Its ability to provide protection against tumour initiation by the chemical carcinogen 7,12-dimethylbenzanthracene (DMBA) has been investigated in t...