Protection against 7,12-dimethylbenzanthracene-induced tumour initiation by protein A in mouse skin

Protein A is an immunostimulating glycoprotein obtained from Staphylococcus aureus Cowan I. Its antitumour activity is proven in various tumour models. Its ability to provide protection against tumour initiation by the chemical carcinogen 7,12-dimethylbenzanthracene (DMBA) has been investigated in t...

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Published inCancer letters Vol. 61; no. 2; pp. 105 - 110
Main Authors Kumar, Sushil, Shukla, Yogeshwer, Prasad, Arun Kumar, Verma, A.S., Dwivedi, P.D., Mehrotra, N.K., Ray, P.K.
Format Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 10.01.1992
Elsevier
Subjects
7,12-dimethylbenzanthracene
9,10-Dimethyl-1,2-benzanthracene
Animal tumors. Experimental tumors
Animals
Antineoplastic Agents
Biological and medical sciences
Experimental skin tumors
Female
Medical sciences
Mice
mouse skin
protein A
Skin Neoplasms - chemically induced
Skin Neoplasms - prevention & control
Staphylococcal Protein A - administration & dosage
Survival Analysis
Tumors
tumour initiation
tumour initiation
mouse skin
protein A
7,12-dimethylbenzanthracene
Skin disease
Intraperitoneal administration
Rodentia
Tumor initiation
Glycoproteins
Anticarcinogen
Multiple dose
Prevention
Vertebrata
Experimental disease
Mammalia
Mouse
Animal
Bacteria
Micrococcales
Tumor
Micrococcaceae
Staphylococcus aureus
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Abstract Protein A is an immunostimulating glycoprotein obtained from Staphylococcus aureus Cowan I. Its antitumour activity is proven in various tumour models. Its ability to provide protection against tumour initiation by the chemical carcinogen 7,12-dimethylbenzanthracene (DMBA) has been investigated in the present study using a mouse skin model of two-stage carcinogenesis. Protein A was administered intraperitoneally (l μg/animal 20 g body wt.) twice a week for 2 weeks, prior to initiation by DMBA. The promotion was performed by twice weekly applications of 12-O-tetradecanoyl phorbol-13-acetate (TPA) (3 or 5 μg/animal in 100 μl acetone). Protein A provided significant protection animals from DMBA-induced tumour initiation as was observed by the decrease in cumulative number of tumours, percent of animals developing tumours, number of tumours per animal and rate of tumour growth. Our data indicate that protein A has anticarcinogenic properties.
AbstractList Protein A is an immunostimulating glycoprotein obtained from Staphylococcus aureus Cowan I. Its antitumour activity is proven in various tumour models. Its ability to provide protection against tumour initiation by the chemical carcinogen 7,12-dimethylbenzanthracene (DMBA) has been investigated in the present study using a mouse skin model of two-stage carcinogenesis. Protein A was administered intraperitoneally (l μg/animal 20 g body wt.) twice a week for 2 weeks, prior to initiation by DMBA. The promotion was performed by twice weekly applications of 12-O-tetradecanoyl phorbol-13-acetate (TPA) (3 or 5 μg/animal in 100 μl acetone). Protein A provided significant protection animals from DMBA-induced tumour initiation as was observed by the decrease in cumulative number of tumours, percent of animals developing tumours, number of tumours per animal and rate of tumour growth. Our data indicate that protein A has anticarcinogenic properties.
Protein A is an immunostimulating glycoprotein obtained from Staphylococcus aureus Cowan I. Its antitumour activity is proven in various tumour models. Its ability to provide protection against tumour initiation by the chemical carcinogen 7,12-dimethylbenzanthracene (DMBA) has been investigated in the present study using a mouse skin model of two-stage carcinogenesis. Protein A was administered intraperitoneally (1 microgram/animal 20 g body wt.) twice a week for 2 weeks, prior to initiation by DMBA. The promotion was performed by twice weekly applications of 12-O-tetradecanoyl phorbol-13-acetate (TPA) (3 or 5 micrograms/animal in 100 microliters acetone). Protein A provided significant protection to animals from DMBA-induced tumour initiation as was observed by the decrease in cumulative number of tumours, percent of animals developing tumours, number of tumours per animal and rate of tumour growth. Our data indicate that protein A has anticarcinogenic properties.
Author Ray, P.K.
Kumar, Sushil
Shukla, Yogeshwer
Prasad, Arun Kumar
Verma, A.S.
Mehrotra, N.K.
Dwivedi, P.D.
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CitedBy_id crossref_primary_10_1006_bbrc_1999_0194
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10.1038/291077a0
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Issue 2
Keywords tumour initiation
mouse skin
protein A
7,12-dimethylbenzanthracene
Skin disease
Intraperitoneal administration
Rodentia
Tumor initiation
Glycoproteins
Anticarcinogen
Multiple dose
Prevention
Vertebrata
Experimental disease
Mammalia
Mouse
Animal
Bacteria
Micrococcales
Tumor
Micrococcaceae
Staphylococcus aureus
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Elsevier
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  article-title: Effect of protein A on mast cell numbers and macrophage phagocytic activity
  publication-title: Immunopharmacol. Immunotoxicol.
  doi: 10.3109/08923978709035215
  contributor:
    fullname: Singh
– volume: 3
  start-page: 39
  year: 1984
  ident: 10.1016/0304-3835(92)90167-T_BIB10
  article-title: Effect of frequency of plasma adsorption over protein A containing Staphylococus aureus on regression of rat mammary adinocarcinoma-modification of antitumour immune response and tumour histopathology
  publication-title: J. Biol. Resp.
  contributor:
    fullname: Ray
– volume: 261
  start-page: 5544
  year: 1986
  ident: 10.1016/0304-3835(92)90167-T_BIB2
  article-title: Overexpression of a novel anionic glutathione transferase in multidrug resistant human breast cancer cells
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)66748-1
  contributor:
    fullname: Batist
– volume: 9
  start-page: 541
  year: 1987
  ident: 10.1016/0304-3835(92)90167-T_BIB6
  article-title: Increased macrophage activity in protein A treated tumour regressed animals
  publication-title: Immunopharmacol. Immunotoxicol.
  doi: 10.3109/08923978709035231
  contributor:
    fullname: Prasad
– volume: 4
  start-page: 59
  year: 1985
  ident: 10.1016/0304-3835(92)90167-T_BIB11
  article-title: Rescue of rats from large doses cyclophosphamide toxicity using protein A
  publication-title: Cancer Chemother. Pharmacol.
  doi: 10.1007/BF00552727
  contributor:
    fullname: Ray
– volume: 8
  start-page: 407
  year: 1988
  ident: 10.1016/0304-3835(92)90167-T_BIB14
  article-title: Protection against CCl4 induced hepatotoxicity by protein A
  publication-title: J. Appl. Toxicol.
  doi: 10.1002/jat.2550080604
  contributor:
    fullname: Singh
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Snippet Protein A is an immunostimulating glycoprotein obtained from Staphylococcus aureus Cowan I. Its antitumour activity is proven in various tumour models. Its...
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StartPage 105
SubjectTerms 7,12-dimethylbenzanthracene
9,10-Dimethyl-1,2-benzanthracene
Animal tumors. Experimental tumors
Animals
Antineoplastic Agents
Biological and medical sciences
Experimental skin tumors
Female
Medical sciences
Mice
mouse skin
protein A
Skin Neoplasms - chemically induced
Skin Neoplasms - prevention & control
Staphylococcal Protein A - administration & dosage
Survival Analysis
Tumors
tumour initiation
Title Protection against 7,12-dimethylbenzanthracene-induced tumour initiation by protein A in mouse skin
URI https://dx.doi.org/10.1016/0304-3835(92)90167-T
https://www.ncbi.nlm.nih.gov/pubmed/1730133
Volume 61
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