Pancreastatin decreases plasma epinephrine levels in surgical stress in the rat

• Published in: Peptides (New York, N.Y. : 1980) Vol. 14; no. 4; pp. 797 - 799
• Main Authors: Sánchez-Margalet, V., Goberna, R.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.1993; Elsevier Science
• Subjects: Adrenals. Interrenals; Adrenomedullary hormones. Regulation; Animals; Biological and medical sciences; Catecholamines; Chromogranin A; Dopamine - blood; Dose-Response Relationship, Drug; Epinephrine - blood; Fundamental and applied biological sciences. Psychology; Injections, Intravenous; Intraoperative Period; Male; Norepinephrine - blood; Pancreastatin; Pancreatic Hormones - pharmacology; Portal Vein; Rat; Rats; Rats, Wistar; Stress, Physiological - blood; Surgical stress; Vertebrates: endocrinology; Surgical stress; Catecholamines; Chromogranin A; Rat; Pancreastatin; Vertebrata; Mammalia; Adrenal hormone; Rodentia; Norepinephrine; Catecholamine; Stress
• ISSN: 0196-9781; 1873-5169
• DOI: 10.1016/0196-9781(93)90116-X

Pancreastatin is a novel peptide, isolated from porcine pancreatic extracts, that is known to be derived from chromogranin A. Since chromogranin A-derived peptides have been shown to control secretion from chromaffin cells, we studied the effect of rat pancreastatin, injected intravenously via portal vein, on plasma catecholamine levels in the anesthetized, laparotomized rat. Rat pancreastatin reversibly decreased plasma epinephrine levels, in a dose-dependent manner, without modifying plasma norepinephrine and dopamine levels. These findings suggest that pancreastatin, released from the gastroenteropancreatic system or derived from chromogranin A, may have a role controlling secretion from the adrenal medulla in surgical stress.