HOX gene methylation status analysis in patients with hereditary breast cancer

• Published in: Journal of human genetics Vol. 58; no. 1; pp. 51 - 53
• Main Authors: Pilato, Brunella, Pinto, Rosamaria, De Summa, Simona, Lambo, Rossana, Paradiso, Angelo, Tommasi, Stefania
• Format: Journal Article
• Language: English
• Published: England 01.01.2013
• Subjects: BRCA1 Protein - genetics; BRCA1 Protein - metabolism; BRCA2 Protein - genetics; BRCA2 Protein - metabolism; Breast Neoplasms - genetics; Breast Neoplasms - pathology; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Genes, Homeobox - genetics; Genetic Predisposition to Disease; Humans; Mutation; Receptor, ErbB-2 - genetics; Receptor, ErbB-2 - metabolism

Cancer development is related not only to genetic alterations but also to aberrant epigenetic changes that could lead to heritable gene patterns critical for neoplastic initiation and progression. Knowledge of epigenetic regulation in cancer cells is useful for both the understanding of carcinogenes...