Mitochondrial Ca2+ influx targets cardiolipin to disintegrate respiratory chain complex II for cell death induction

• Published in: Cell death and differentiation Vol. 21; no. 11; pp. 1733 - 1745
• Main Authors: Hwang, M-S, Schwall, C T, Pazarentzos, E, Datler, C, Alder, N N, Grimm, S
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2014; Nature Publishing Group
• Subjects: 13/109; 13/2; 13/31; 13/89; 13/95; 14/1; 14/19; 631/80; Apoptosis; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Cycle Analysis; Cell death; Life Sciences; Original Paper; Stem Cells

Massive Ca 2+ influx into mitochondria is critically involved in cell death induction but it is unknown how this activates the organelle for cell destruction. Using multiple approaches including subcellular fractionation, FRET in intact cells, and in vitro reconstitutions, we show that mitochondrial...