Inhibition of proteoglycan synthesis by hydrogen peroxide in cultured bovine articular cartilage

• Published in: Biochimica et biophysica acta Vol. 838; no. 2; pp. 221 - 228
• Main Authors: Bates, Edna J., Johnson, Colin C., Lowther, Dennis A.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15.02.1985; Elsevier; North-Holland
• Subjects: Animals; Biological and medical sciences; Bovine articular cartilage; Cartilage, Articular - drug effects; Cartilage, Articular - metabolism; Cattle; Fundamental and applied biological sciences. Psychology; Hydrogen peroxide; Hydrogen Peroxide - pharmacology; Inflammation; L-Lactate Dehydrogenase - metabolism; Molecular and cellular biology; Pentetic Acid - pharmacology; Proteoglycan synthesis; Proteoglycans - biosynthesis; Xanthine Oxidase - metabolism; DETAPAC; Hydrogen peroxide; Bovine articular cartilage; Proteoglycan synthesis; Proteoglycan; Vertebrata; Mammalia; Hydrogene peroxyde; Articular cartilage; Tissue culture; Biosynthesis; Artiodactyla; Beef; Inhibition; Ungulata

Oxygen-derived reactive species, generated enzymatically by the action of xanthine oxidase upon hypoxanthine, significantly inhibit proteoglycan synthesis by cultured bovine articular cartilage (Bates, E.J., Lowther, D.A. and Handley, C.J. (1984) Ann. Rheum. Dis. 43, 462–469). Here we extend these i...