Revealing the role of serum exosomal novel long non-coding RNA NAMPT-AS as a promising diagnostic/prognostic biomarker in colorectal cancer patients

• Published in: Life sciences (1973) Vol. 352; p. 122850
• Main Authors: Rizk, Nehal I., Kassem, Dina H., Abulsoud, Ahmed I., AbdelHalim, Sherif, Yasser, Montaser Bellah, Kamal, Mohamed M., Hamdy, Nadia M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.09.2024
• Subjects: Aged; biomarkers; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; blood serum; breast neoplasms; Colorectal cancer; colorectal neoplasms; Colorectal Neoplasms - blood; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; Cytokines - blood; Cytokines - genetics; Exosomes; Exosomes - genetics; Exosomes - metabolism; Extracellular vesicles; Female; Gene Expression Regulation, Neoplastic; genome; Humans; immunohistochemistry; Long non-coding RNA; Male; Middle Aged; NAMPT; NAMPT-antisense; nicotinamide; Nicotinamide Phosphoribosyltransferase - blood; Nicotinamide Phosphoribosyltransferase - genetics; non-coding RNA; Prognosis; RNA, Long Noncoding - blood; RNA, Long Noncoding - genetics; NAMPT-antisense; Extracellular vesicles; Exosomes; Colorectal cancer; NAMPT; Long non-coding RNA
• ISSN: 0024-3205; 1879-0631; 1879-0631
• DOI: 10.1016/j.lfs.2024.122850

Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Nicotinamide phosphoribosyl-transferase (NAMPT) was found to be over-expressed in several cancers including CRC. NAMPT-Antisense (NAMPT-AS) is a novel long non-coding RNA (lncRNA) recently reported to be associat...