Obesity and breast cancer – Role of estrogens and the molecular underpinnings of aromatase regulation in breast adipose tissue

• Published in: Molecular and cellular endocrinology Vol. 466; pp. 15 - 30
• Main Authors: Gérard, Céline, Brown, Kristy A.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 05.05.2018
• Subjects: adipocytes; Adipose Tissue, White - enzymology; Animals; Aromatase; Aromatase - metabolism; biochemical pathways; biosynthesis; Breast cancer; breast neoplasms; Breast Neoplasms - enzymology; Breast Neoplasms - pathology; breasts; Disease Models, Animal; Estrogen; estrogens; Estrogens - metabolism; Female; females; Humans; Inflammation; Inflammation - enzymology; Inflammation - pathology; Mice; Mice, Transgenic; Obesity; Obesity - enzymology; Obesity - pathology; postmenopause; Postmenopause - physiology; Risk Factors; signal transduction; white adipose tissue; women; Obesity; Breast cancer; Inflammation; Aromatase; Estrogen

One in eight women will develop breast cancer over their lifetime making it the most common female cancer. The cause of breast cancer is multifactorial and includes hormonal, genetic and environmental cues. Obesity is now an accepted risk factor for breast cancer in postmenopausal women, particularl...