Lipid-Associated Macrophages Are Induced by Cancer-Associated Fibroblasts and Mediate Immune Suppression in Breast Cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 82; no. 18; pp. 3291 - 3306
• Main Authors: Timperi, Eleonora, Gueguen, Paul, Molgora, Martina, Magagna, Ilaria, Kieffer, Yann, Lopez-Lastra, Silvia, Sirven, Philemon, Baudrin, Laura G., Baulande, Sylvain, Nicolas, André, Champenois, Gabriel, Meseure, Didier, Vincent-Salomon, Anne, Tardivon, Anne, Laas, Enora, Soumelis, Vassili, Colonna, Marco, Mechta-Grigoriou, Fatima, Amigorena, Sebastian, Romano, Emanuela
• Format: Journal Article
• Language: English
• Published: American Association for Cancer Research 16.09.2022
• Subjects: Life Sciences

Tumor-associated macrophages (TAM) play a detrimental role in triple-negative breast cancer (TNBC). In-depth analysis of TAM characteristics and interactions with stromal cells, such as cancer-associated fibroblast (CAF), could provide important biological and therapeutic insights. Here we identify...