m6A demethylase ALKBH5 maintains stemness of intrahepatic cholangiocarcinoma by sustaining BUB1B expression and cell proliferation

• Published in: Translational oncology Vol. 41; p. 101858
• Main Authors: Gao, Yuan, Yu, Miao, Liu, Zengyuan, Liu, Yi, Kong, Zhijun, Zhu, Chunfu, Qin, Xihu, Li, Yan, Tang, Liming
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.03.2024; Neoplasia Press; Elsevier
• Subjects: ALKBH5; BUB1B; Cancer cell stemness; ICC; Original Research; ICC; BUB1B; ALKBH5; Cancer cell stemness

•ALKBH5 predicted poor overall survival in ICC.•Stemness of ICC was kept well by overexpression of ALKBH5.•ALKBH5 enhanced BUB1B expression to promote ICC progress. ALKBH5 plays critical roles in various cellular processes via post-transcriptional regulation of oncogenes or tumor suppressors in an N...