Detection of apoptosis by PET/CT with the diethyl ester of [18F]ML-10 and fluorescence imaging with a dansyl analogue

The diethyl ester of [18F]ML-10 is a small molecule apoptotic PET probe for cancer studies. Here we report a novel multi-step synthesis of the diethyl ester of ML-10 in excellent yields via fluorination using Xtal-Fluor-E. In addition, a one-pot radiosynthesis of the diethyl ester of [18F]ML-10 from...

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Bibliographic Details
Published inBioorganic & medicinal chemistry Vol. 22; no. 1; pp. 341 - 349
Main Authors Kadirvel, Manikandan, Fairclough, Michael, Cawthorne, Christopher, Rowling, Emily J., Babur, Muhammad, McMahon, Adam, Birkket, Paul, Smigova, Alison, Freeman, Sally, Williams, Kaye J., Brown, Gavin
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.01.2014
Elsevier
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