Day 4 bone marrow aspirate for prediction of resistance to induction chemotherapy in acute myeloid leukemia

• Published in: Leukemia research Vol. 11; no. 3; pp. 281 - 283
• Main Authors: Archimbaud, Eric, Treille-Ritouet, Danièle, Guyotat, Denis, Viala, Jean-Jacques, Fiere, Denis
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 1987; Elsevier Science
• Subjects: acute myeloid leukemia; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic agents; Biological and medical sciences; Bone Marrow - pathology; Bone marrow aspirate; Chemotherapy; Drug Resistance; Humans; Leukemia, Myeloid, Acute - drug therapy; Leukemia, Myeloid, Acute - pathology; Medical sciences; Middle Aged; Pharmacology. Drug treatments; predictive tests; Prognosis; Time Factors; AML; RD; acute myeloid leukemia; FAB; OF; predictive tests; Bone marrow aspirate; chemotherapy; araC; CR; Therapeutic efficiency; Human; Polychemotherapy; Prognosis; Sensitivity resistance; Biopsy; Bone marrow; Malignant hemopathy; Induction treatment; Acute myelocytic leukemia

Bone marrow aspirate was performed on day 4 of a 7-day induction chemotherapy regimen using daunorubicin, cytosine arabinoside and thioguanine in 42 patients with acute myeloid leukemia (AML). The mean percentage of remaining abnormal cells in day 4 bone marrow was significantly higher in patients h...