Regulation of the β-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis

• Published in: Molecular and cellular endocrinology Vol. 478; pp. 106 - 114
• Main Authors: Ghiasi, Seyed Mojtaba, Dahllöf, Mattias Salling, Osmai, Yama, Osmai, Mirwais, Jakobsen, Kathrine Kronberg, Aivazidis, Alexander, Tyrberg, Björn, Perruzza, Lisa, Prause, Michala Cecilie Burstein, Christensen, Dan Ploug, Fog-Tonnesen, Morten, Lundh, Morten, Grassi, Fabio, Chatenoud, Lucienne, Mandrup-Poulsen, Thomas
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 15.12.2018
• Subjects: Animals; apoptosis; Apoptosis - drug effects; ASC; autocrine signaling; CARD Signaling Adaptor Proteins; Cell Death - drug effects; Cell Line; Cytokines - pharmacology; Cytoprotection - drug effects; cytotoxicity; Danger associated-molecular patterns; Female; Glucose - toxicity; Histone Deacetylases - metabolism; Humans; inflammasomes; Inflammasomes - metabolism; Inflammation; insulin secretion; Insulin Secretion - drug effects; Insulin-Secreting Cells - drug effects; Insulin-Secreting Cells - metabolism; interleukin-1beta; Interleukin-1beta - metabolism; islets of Langerhans; JNK Mitogen-Activated Protein Kinases - metabolism; Lipids - toxicity; Middle Aged; nitric oxide; Potassium; Potassium - pharmacology; Purinergic receptors; Rats; Receptors, Purinergic P2X7 - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Stress, Physiological - drug effects; Young Adult; NO; Purinergic receptors; JNK; Inflammation; Danger associated-molecular patterns; NLRC; HDACi/KDACi; CARD; P2RX7; ASC; GSIS; KDAC; NLRP; KD; SFN; Potassium; HDAC

β-Cells may be a source of IL-1β that is produced as inactive pro-IL-1β and processed into biologically-active IL-1β by enzymatic cleavage mediated by the NLRP1-, NLRP3- and NLRC4-inflammasomes. Little is known about the β-cell inflammasomes. NLRP1-expression was upregulated in islet-cells from T2D-...