Regulation of the β-cell inflammasome and contribution to stress-induced cellular dysfunction and apoptosis - Ghiasi, Seyed Mojtaba; Dahllöf, Mattias Salling; Osmai, Yama; Osmai, Mirwais; Jakobsen, Kathrine Kronberg; Aivazidis, Alexander; Tyrberg, Björn; Perruzza, Lisa; Prause, Michala Cecilie Burstein; Christensen, Dan Ploug; Fog-Tonnesen, Morten; Lundh, Morten; et al. (Molecular and cellular endocrinology, 2018)
Keywords: Animals; apoptosis; Apoptosis - drug effects; ASC; autocrine signaling; CARD Signaling Adaptor Proteins; Cell Death - drug effects; Cell Line; Cytokines - pharmacology; Cytoprotection - drug effects; cytotoxicity; Danger associated-molecular patterns; Female; Glucose - toxicity; Histone Deacetylases - metabolism; Humans; inflammasomes; Inflammasomes - metabolism; Inflammation; insulin secretion; Insulin Secretion - drug effects; Insulin-Secreting Cells - drug effects; Insulin-Secreting Cells - metabolism; interleukin-1beta; Interleukin-1beta - metabolism; islets of Langerhans; JNK Mitogen-Activated Protein Kinases - metabolism; Lipids - toxicity; Middle Aged; nitric oxide; Potassium; Potassium - pharmacology; Purinergic receptors; Rats; Receptors, Purinergic P2X7 - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Stress, Physiological - drug effects; Young Adult; NO; Purinergic receptors; JNK; Inflammation; Danger associated-molecular patterns; NLRC; HDACi/KDACi; CARD; P2RX7; ASC; GSIS; KDAC; NLRP; KD; SFN; Potassium; HDAC