Understanding modularity in molecular networks requires dynamics

• Published in: Science signaling Vol. 2; no. 81; p. pe44
• Main Authors: Alexander, Roger P, Kim, Philip M, Emonet, Thierry, Gerstein, Mark B
• Format: Journal Article
• Language: English
• Published: United States 28.07.2009
• Subjects: Animals; Cell Communication - physiology; Drosophila melanogaster - metabolism; Drosophila Proteins - metabolism; Kinetics; Mitogen-Activated Protein Kinases - metabolism; Models, Biological; PC12 Cells; Proto-Oncogene Proteins p21(ras) - metabolism; raf Kinases - metabolism; Rats; Signal Transduction

The era of genome sequencing has produced long lists of the molecular parts from which cellular machines are constructed. A fundamental goal in systems biology is to understand how cellular behavior emerges from the interaction in time and space of genetically encoded molecular parts, as well as non...