Schiff base formation with amino acids enhances light emission and damage induced in neutrophils by phenylacetaldehyde

• Published in: Biochimica et biophysica acta Vol. 991; no. 1; pp. 50 - 55
• Main Authors: Nascimento, Ana Lucia T.O., Cilento, Giuseppe
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 25.04.1989; Elsevier; North-Holland
• Subjects: Acetaldehyde - analogs & derivatives; Acetaldehyde - pharmacology; Amino Acids - pharmacology; Analytical, structural and metabolic biochemistry; Animals; Biological and medical sciences; Chemiluminiscence; Chlorophyll - metabolism; Enzymes and enzyme inhibitors; Fundamental and applied biological sciences. Psychology; Kinetics; Luminescent Measurements; Myeloperoxidase; Neutrophil; Neutrophils - drug effects; Neutrophils - metabolism; Oxidoreductases; Oxygen Consumption; Peroxidase - metabolism; Phenylacetaldehyde; Photochemistry; Rats; Rats, Inbred Strains; Schiff base oxidation; Schiff Bases - pharmacology; Spectrometry, Fluorescence; Schiff base oxidation; Myeloperoxidase; Neutrophil; Chemiluminiscence; Phenylacetaldehyde; Schiff base; Enzyme; Neutrophile; Aminoacid; Spectral properties; Chemiluminescence; Peroxidase

The light emission and the loss of cell viability observed when phenylacetaldehyde is added to neutrophils are greatly enhanced when phenylacetaldehyde is administered as a Schiff base with amino acids. As in the case of phenylacetaldehyde, the Schiff base undergoes an intracellular, myeloperoxidase...