Exposure to low-level metalaxyl impacts the cardiac development and function of zebrafish embryos

• Published in: Journal of environmental sciences (China) Vol. 85; pp. 1 - 8
• Main Authors: Wu, Yuqiong, Zhang, Ying, Chen, Meng, Yang, Qihong, Zhuang, Shanshan, Lv, Liangju, Zuo, Zhenghong, Wang, Chonggang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2019
• Subjects: abnormal development; adenosinetriphosphatase; Anilide pesticides; arrhythmia; ATPase activity; Ca2-transporting ATPase; calcium channels; Cardiac development; cardiac output; Danio rerio; disease control; edema; embryo (animal); enzyme activity; Fish; GATA transcription factors; gene expression regulation; genes; heart; heart rate; hemorrhage; larvae; Mechanism; messenger RNA; metalaxyl; mRNA level; pericardium; Peronosporales; sodium-potassium-exchanging ATPase; solvents; toxicity; Fish; Cardiac development; mRNA level; Anilide pesticides; ATPase activity; Mechanism

Metalaxyl is an anilide pesticide that is widely used to control plant diseases caused by Peronosporales species. In order to study the toxic effects, zebrafish embryos were exposed to metalaxyl at nominal concentrations of 5, 50 and 500 ng/L for 72 hr, and the cardiac development and functioning of...