Insulin resistance in total lipodystrophy: evidence for a pre-receptor defect in insulin action

• Published in: Metabolism, clinical and experimental Vol. 34; no. 4; p. 330
• Main Authors: Golden, M P, Charles, M A, Arquilla, E R, Myers, G L, Lippe, B M, Duckworth, W C, Zuniga, O F, Tanner, S M, Palmer, A M, Spell, M
• Format: Journal Article
• Language: English
• Published: United States 01.04.1985
• Subjects: Adolescent; Diabetes Mellitus, Lipoatrophic - blood; Erythrocytes - metabolism; Female; Humans; Immunoglobulins - metabolism; Insulin - blood; Insulin Resistance; Metabolic Clearance Rate; Monocytes - metabolism; Protein Binding; Receptor, Insulin - metabolism

The cause of insulin resistance in lipodystrophic diabetes is unknown but has generally been ascribed to dysfunction at either the receptor or post receptor level. In a 14 year-old girl with total acquired lipodystrophy, subcutaneous and intravenous insulin requirements approximated 600 units daily....