Genome-wide identification, immune response profile and functional characterization of IL-10 from spotted knifejaw (Oplegnathus punctatus) during host defense against bacterial and viral infection

• Published in: Fish & shellfish immunology Vol. 124; pp. 513 - 524
• Main Authors: Wang, Jie, Chen, Zhangfan, Li, Ming, Ziwei zhang, Song, Yu, Xu, Wenteng, Wang, Lei, Chen, Songlin
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2022
• Subjects: Animals; Bass - metabolism; Epinephelus lanceolatus; family; fish; Fish Diseases; Fish Proteins; Gene Expression Regulation; genome; immune response; Immunity; Innate immune response; Interleukin-10; Interleukin-10 - genetics; Interleukin-10 - metabolism; interleukin-12; interleukin-6; interleukin-8; intestines; intracellular signaling peptides and proteins; Iridovirus; kidneys; liver; NF-kappa B - metabolism; Notolabrus; Oplegnathus; Oplegnathus punctatus; Phylogeny; polyinosinic-polycytidylic acid; shellfish; spleen; Spotted knifejaw iridovirus; Vibrio harveyi; Virus Diseases; Oplegnathus punctatus; Interleukin-10; Vibrio harveyi; Spotted knifejaw iridovirus; Innate immune response

Interleukin 10 (IL-10), a pleiotropic cytokine, plays an essential role in multiple immunity responses. In the current study, the sequences of IL-10 family were identified from spotted knifejaw (Oplegnathus punctatus) whole genome, and O. punctatus IL-10 (OpIL-10) was cloned and characterized. OpIL-...