Comparison of desmethylsertraline with sertraline as a monoamine uptake inhibitor in vivo

• Published in: Progress in neuro-psychopharmacology & biological psychiatry Vol. 19; no. 1; pp. 135 - 149
• Main Authors: Fuller, Ray W., Hemrick-Luecke, Susan K., Littlefield, Ethel S., Audia, James E.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 1995; Elsevier
• Subjects: 1-Naphthylamine - analogs & derivatives; 1-Naphthylamine - chemistry; 1-Naphthylamine - pharmacology; 5-hydroxyindoleacetic acid; 6-hydroxydopamine; Animals; Biological and medical sciences; desmethylsertraline; Dose-Response Relationship, Drug; Epinephrine - pharmacology; Hydroxyindoleacetic Acid - metabolism; Male; Medical sciences; Mice; Neuropharmacology; Norepinephrine - pharmacology; Oxidopamine - pharmacology; p-chloroamphetamine; Pharmacology. Drug treatments; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; serotonin; Serotonin Uptake Inhibitors - chemistry; Serotonin Uptake Inhibitors - pharmacology; Sertraline; p-chloroamphetamine; 5-hydroxyindoleacetic acid; 6-hydroxydopamine; serotonin; desmethylsertraline; sertraline; Intraperitoneal administration; Rat; Serotonin; Metabolite; Psychotropic; Rodentia; Reuptake inhibitor; Metabolism; Activity metabolism relation; Vertebrata; Mammalia; Mouse; Animal; Neuromediator; Antidepressant agent; Comparative study

1. 1. Desmethylsertraline, a metabolite of the antidepressant drug sertraline, was compared with sertraline for its ability to produce effects characteristic of inhibitors of the serotonin transporter in vivo. Desmethylsertraline antagonized brain serotonin depletion by p-chloroamphetamine, a deplet...