Dietary effects of Sideritis scardica “mountain tea” on human in vivo activities of xenobiotic metabolizing enzymes in healthy subjects

• Published in: Food and chemical toxicology Vol. 122; pp. 38 - 48
• Main Authors: Begas, Elias, Kilindris, Thomas, Kouvaras, Evangelos, Tsioutsioumi, Agoritsa, Kouretas, Demetrios, Asprodini, Eftihia K.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2018
• Subjects: acetaminophen; Acetaminophen - metabolism; Adult; aerial parts; Arylamine N-Acetyltransferase - metabolism; Arylamine N-Acetyltransferase - urine; caffeine; Caffeine - metabolism; CYP1A2; CYP2A6; Cytochrome P-450 CYP1A2 - metabolism; Cytochrome P-450 CYP1A2 - urine; Cytochrome P-450 CYP2A6 - metabolism; Cytochrome P-450 CYP2A6 - urine; Dietary Exposure; digestive system diseases; enzymes; Female; Glucuronosyltransferase - metabolism; Glucuronosyltransferase - urine; Healthy Volunteers; Herb-Drug Interactions; herbal tea; Humans; indigenous species; inflammation; Male; males; metabolism; metabolites; Middle Aged; NAT2; phenotype; Plant Components, Aerial; plants (botany); saliva; Saliva - enzymology; sexual dimorphism; Sideritis; Substrate Specificity; Teas, Herbal; toxicology; UDPGlucuronosyltransferases 1A1/1A6; urine; Xanthine oxidase; Xanthine Oxidase - metabolism; Xanthine Oxidase - urine; xenobiotics; Xenobiotics - metabolism; Young Adult; UDPGlucuronosyltransferases 1A1/1A6; Xanthine oxidase; CYP2A6; Sideritis; NAT2; CYP1A2

Sideritis scardica(S. scardica) is an endemic plant of the Balkan Peninsula traditionally used as herbal tea for inflammation and gastric disorders. Aqueous herbal extracts may affect the activity of Phase I and II enzymes involved in xenobiotic metabolism. The purpose of the present study was to de...