Molecular evidence links lymphomatous polyposis of the gastrointestinal tract with mantle cell lymphoma

• Published in: Human pathology Vol. 26; no. 11; pp. 1282 - 1285
• Main Authors: Smir, Bassam N, Ramaika, Catherine A, Cho, Chong G, Gulley, Margaret L
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.11.1995; Elsevier
• Subjects: Base Sequence; bcl-1; Biological and medical sciences; Biopsy; Blotting, Southern; Cyclin D1; DNA Primers - chemistry; DNA Probes - analysis; DNA Probes - chemistry; DNA Probes - genetics; DNA, Neoplasm - analysis; DNA, Neoplasm - chemistry; DNA, Neoplasm - genetics; Gastrointestinal Neoplasms - diagnosis; Gastrointestinal Neoplasms - genetics; Gastrointestinal Neoplasms - pathology; gastrointestinal polyp; Hematologic and hematopoietic diseases; Humans; Immunoglobulin Heavy Chains - genetics; Immunophenotyping; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymph Nodes - pathology; Lymphoma, Non-Hodgkin - diagnosis; Lymphoma, Non-Hodgkin - genetics; Lymphoma, Non-Hodgkin - pathology; Male; Medical sciences; Middle Aged; Molecular Sequence Data; non-Hodgkin's lymphoma; Polymerase Chain Reaction; polyposis; Polyps - diagnosis; Polyps - genetics; Polyps - pathology; Proto-Oncogene Proteins - genetics; Translocation, Genetic; gastrointestinal polyp; LP; non-Hodgkin's lymphoma; dNTP; bcl-1; MTC; polyposis; PCR; JH; MALT; Human; Immunohistochemistry; Pathogenesis; Lymphomatous polyposis; Malignant hemopathy; Gastrointestinal; Non Hodgkin lymphoma; Case study; Polymerase chain reaction; Pathology; Lymphoproliferative syndrome; Mantle cell lymphoma; Digestive diseases; Molecular biology; Southern blotting

Lymphomatous polyposis (LP) is a subtype of non-Hodgkin's lymphoma manifested by numerous polyps affecting long segments of the gastrointestinal tract. The malignant cells of LP often share morphological and immunophenotypic similarity with cells of nodal-based mantle cell lymphoma. Recent gene...