HDAC1 participates in polycystic ovary syndrome through histone modification by regulating H19/miR-29a-3p/NLRP3-mediated granulosa cell pyroptosis

• Published in: Molecular and cellular endocrinology Vol. 573; p. 111950
• Main Authors: Chen, Jiying, Zhu, Zhiying, Xu, Shi, Li, Jing, Huang, Lilan, Tan, Wenqing, Zhang, Yonggang, Zhao, Yanli
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.08.2023
• Subjects: Animals; blood serum; cytokines; dihydrotestosterone; etiology; Female; granulosa cells; Granulosa Cells - metabolism; HDAC1; Histone Code; histone deacetylase; Histone Deacetylase 1 - genetics; Histone Deacetylase 1 - metabolism; Humans; LncRNA H19; Mice; MicroRNAs - genetics; MicroRNAs - metabolism; miR-29a-3p; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; NLRP3; Polycystic ovary syndrome; Polycystic Ovary Syndrome - genetics; Polycystic Ovary Syndrome - metabolism; prasterone; Pyroptosis; Polycystic ovary syndrome; NLRP3; LncRNA H19; HDAC1; miR-29a-3p

Histone deacetylase 1 (HDAC1) is known to participate in the molecular etiology of polycystic ovary syndrome (PCOS). However, its role in granulosa cell (GC) pyroptosis remains unclear. This study sought to investigate the mechanism of HDAC1 in PCOS-induced GC pyroptosis through histone modification...