Aluminium accumulation in relation to senile plaque and neurofibrillary tangle formation in the brains of patients with renal failure

• Published in: Journal of the neurological sciences Vol. 107; no. 2; pp. 210 - 218
• Main Authors: Candy, J.M., McArthur, F.K., Oakley, A.E., Taylor, G.A., Chen, C.P.L.-H., Mountfort, S.A., Thompson, J.E., Chalker, P.R., Bishop, H.E., Beyreuther, K., Perry, G., Ward, M.K., Martyn, C.N., Edwardson, J.A.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier B.V 01.02.1992; Elsevier Science
• Subjects: [formula omitted] Amyloid protein; Aluminium; Aluminum - analysis; Aluminum - metabolism; Aluminum - toxicity; Amyloid beta-Peptides - analysis; Amyloid beta-Protein Precursor - analysis; Antibodies, Monoclonal; Biological and medical sciences; Brain - drug effects; Brain - metabolism; Brain - pathology; Female; Human brain; Humans; Immunocytochemistry; Immunohistochemistry; Kidney Failure, Chronic - metabolism; Kidney Failure, Chronic - pathology; Kidney Failure, Chronic - therapy; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Neurofibrillary tangle; Neurofibrillary Tangles - ultrastructure; Peritoneal Dialysis - adverse effects; Reference Values; Renal dialysis; Renal Dialysis - adverse effects; Renal failure; Retrospective Studies; Secondary ion mass spectrometry; Senile plaque; Immunocytochemistry; Senile plaque; Human brain; Renal dialysis; Secondary ion mass spectrometry; Aluminium; Neurofibrillary tangle; β A4 Amyloid protein; Human; Nervous system diseases; Urinary system disease; Senile plate; Exploration; Pathology; Chronic; Renal failure; Dialysis; Brain (vertebrata)

The effects of long-term exposure to aluminium on the development of Alzheimer-type neuropathological changes have been studied post-mortem in patients with chronic renal failure who did not have dialysis encephalopathy. Administration of aluminium-containing phosphate binding compounds appears to b...