Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression

• Published in: Journal of genetics and genomics Vol. 47; no. 2; pp. 69 - 83
• Main Authors: Wang, Raoxu, Li, Bowen, Lam, Sin Man, Shui, Guanghou
• Format: Journal Article
• Language: English
• Published: China Elsevier Ltd 20.02.2020
• Subjects: amino acids; Disease Progression; human diseases; Humans; hydrophilicity; Integration; Lipid Metabolism - genetics; Lipidomics; lipids; Lipids - chemistry; Lipids - genetics; Mass Spectrometry; metabolites; metabolome; Metabolome - genetics; Metabolomics; organic acids and salts; pathogenesis; phenotype; public health; sugars; tissues; T1DM; APP; PS; IRS1; IDA; ATPs; MuS; Lp-PLA2; PEBP4; VLDL; VLC-SMs; rCCA; TAGs; NOD; AD; TRPC6; Lyso-PI; MS; Lipidomics; IR; Lyso-PC; SERCA; ER; IL-6; Lyso-PA; PCA; CVD; sPLS; FFAs; SAA; TCA; LOX; RF; FA; DHA; BCAA; RP; DDA; TMAO; Metabolomics; T2DM; BCKD; MFA; CYP7A1; LDL; MMSE; SVZ; CSF; PDKs; SM; DIA; HILIC; SR; CCA; Integration; pPC; pPE; NMF; Disease progression; CL; TMA; DAG; COX; sPCA; PA; LC-MS; NMR; PC; PD; PE; PLs; PH; PI; PIPs; HD; PUFAs

Mass spectrometry (MS)-based omics technologies are now widely used to profile small molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic phenotypes. The metabolomes of cells, tissues, and organisms comprise a variety of molecules including lipids, amino acids, suga...