Interaction of low density lipoproteins with arterial proteoglycans The role of charge and sialic acid content

• Published in: Atherosclerosis Vol. 55; no. 1; pp. 93 - 105
• Main Authors: Camejo, Germán, López, Aura, López, Flor, Quiñones, Jorge
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.04.1985; Elsevier
• Subjects: Arterial; Arteries - analysis; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Humans; Isoelectric Point; Lipoproteins, LDL - analysis; Low density lipoproteins; Medical sciences; Microscopy, Electron; Neuraminidase - metabolism; Proteoglycans - analysis; Sialic acid content; Sialic Acids - analysis; Surface charge; Surface charge; Arterial; Sialic acid content; Low density lipoproteins; Proteoglycan; Sialic acid; Artery; Atherosclerosis; Β-Lipoprotein

The interaction of low density lipoproteins (LDL) with chondroitin sulfate-rich arterial proteoglycans appears to be initiated by coulombic interactions that lead to insoluble complexes. Once formed, large LDL aggregates are held together by non-polar associations. The irreversible formation of LDL...