Calcitonin serum levels in heroin addicts: Effects of methadone and clonidine detoxication treatments
Calcitonin (CT), a 32-aminoacid peptide, is secreted by the parafollicular ‘C’ cells of the thyroid which derive from the ultimobranchial body and, ultimately, from the neural crest. In man, the main role of this hormone is to protect the skeleton during periods of physiological stress, such as grow...
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Published in | Drug and alcohol dependence Vol. 16; no. 2; pp. 181 - 183 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier Ireland Ltd
01.11.1985
Elsevier Science |
Subjects | |
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Abstract | Calcitonin (CT), a 32-aminoacid peptide, is secreted by the parafollicular ‘C’ cells of the thyroid which derive from the ultimobranchial body and, ultimately, from the neural crest. In man, the main role of this hormone is to protect the skeleton during periods of physiological stress, such as growth, pregnancy and lactation by reducing calcium loss [1]. Nevertheless some recent data, such as the finding of immunoreactive CT-like material (iCT) in the central nervous system [2] and in the cerebrospinal fluid and the demonstration of its analgesic action in rabbits [4] and in man [5] indicate a relationship between CT and the neuroendocrine system.
The purpose of the present study is to evaluate the levels of CT in a group of addicts to heroin both before and during detoxication treatment with methadone or a non-opioid drug like clonidine. |
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AbstractList | Calcitonin (CT), a 32-aminoacid peptide, is secreted by the parafollicular ‘C’ cells of the thyroid which derive from the ultimobranchial body and, ultimately, from the neural crest. In man, the main role of this hormone is to protect the skeleton during periods of physiological stress, such as growth, pregnancy and lactation by reducing calcium loss [1]. Nevertheless some recent data, such as the finding of immunoreactive CT-like material (iCT) in the central nervous system [2] and in the cerebrospinal fluid and the demonstration of its analgesic action in rabbits [4] and in man [5] indicate a relationship between CT and the neuroendocrine system.
The purpose of the present study is to evaluate the levels of CT in a group of addicts to heroin both before and during detoxication treatment with methadone or a non-opioid drug like clonidine. Calcitonin (CT), a 32-aminoacid peptide, is secreted by the parafollicular 'C' cells of the thyroid which derive from the ultimobranchial body and, ultimately, from the neural crest. In man, the main role of this hormone is to protect the skeleton during periods of physiological stress, such as growth, pregnancy and lactation by reducing calcium loss [1]. Nevertheless, some recent data, such as the finding of immunoreactive CT-like material (iCT) in the central nervous system [2] and in the cerebrospinal fluid and the demonstration of its analgesic action in rabbits [4] and in man [5] indicate a relationship between CT and the neuroendocrine system. The purpose of the present study is to evaluate the levels of CT in a group of addicts to heroin both before and during detoxication treatment with methadone or a non-opioid drug like clonidine. |
Author | Dorizzi, R. Lafisca, S. Maschio, S. Marigo, M. Tagliaro, F. |
Author_xml | – sequence: 1 givenname: F. surname: Tagliaro fullname: Tagliaro, F. organization: Istituto di Medicina Legale e delle Assicurazioni, Università di Verona, Verona Italy – sequence: 2 givenname: R. surname: Dorizzi fullname: Dorizzi, R. organization: Istituto di Chimica e Microscopia Clinica, Università di Verona, Verona Italy – sequence: 3 givenname: S. surname: Lafisca fullname: Lafisca, S. organization: Istituto di Medicina Legale e delle Assicurazioni, Università di Verona, Verona Italy – sequence: 4 givenname: S. surname: Maschio fullname: Maschio, S. organization: Istituto di Medicina Legale e delle Assicurazioni, Università di Verona, Verona Italy – sequence: 5 givenname: M. surname: Marigo fullname: Marigo, M. organization: Istituto di Medicina Legale e delle Assicurazioni, Università di Verona, Verona Italy |
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Keywords | Clonidine Methadone Heroin addiction Calcitonin Human Drug abuse Chemotherapy Deintoxication |
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References | Fraioli (BIB5) 1982; 78 Deftos (BIB2) 1978; 47 Tagliaro (BIB6) 1983; 35 Tolis, Hickey, Guyda (BIB9) 1975; 41 Pecile (BIB4) 1975; 31 Baylin (BIB8) 1979; 48 Body, Heath (BIB7) 1983; 57 MacIntyre, Stevenson (BIB1) 1981; 80 Pavlinac (BIB3) 1980; 50 MacIntyre (10.1016/0376-8716(85)90116-4_BIB1) 1981; 80 Pavlinac (10.1016/0376-8716(85)90116-4_BIB3) 1980; 50 Pecile (10.1016/0376-8716(85)90116-4_BIB4) 1975; 31 Body (10.1016/0376-8716(85)90116-4_BIB7) 1983; 57 Deftos (10.1016/0376-8716(85)90116-4_BIB2) 1978; 47 Baylin (10.1016/0376-8716(85)90116-4_BIB8) 1979; 48 Tagliaro (10.1016/0376-8716(85)90116-4_BIB6) 1983; 35 Fraioli (10.1016/0376-8716(85)90116-4_BIB5) 1982; 78 Tolis (10.1016/0376-8716(85)90116-4_BIB9) 1975; 41 |
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Snippet | Calcitonin (CT), a 32-aminoacid peptide, is secreted by the parafollicular ‘C’ cells of the thyroid which derive from the ultimobranchial body and, ultimately,... Calcitonin (CT), a 32-aminoacid peptide, is secreted by the parafollicular 'C' cells of the thyroid which derive from the ultimobranchial body and, ultimately,... |
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SubjectTerms | Adolescent Adult Biological and medical sciences Calcitonin Calcitonin - blood Clonidine Clonidine - therapeutic use Drug addictions Female Heroin addiction Heroin Dependence - blood Heroin Dependence - rehabilitation Humans Male Medical sciences Methadone Methadone - therapeutic use Radioimmunoassay Toxicology |
Title | Calcitonin serum levels in heroin addicts: Effects of methadone and clonidine detoxication treatments |
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