Interactions of U937 macrophage-like cells with decellularized pericardial matrix materials: Influence of crosslinking treatment

• Published in: Acta biomaterialia Vol. 9; no. 7; pp. 7191 - 7199
• Main Authors: McDade, Jonathan K., Brennan-Pierce, Ellen P., Ariganello, Marianne B., Labow, Rosalind S., Michael Lee, J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2013
• Subjects: acid phosphatase; Animals; biocompatible materials; Cattle; Cell Line; Cell Proliferation; Cell Survival - physiology; Cell-Free System; Collagen; Cross-Linking Reagents - chemistry; Crosslinking; cultured cells; cytokines; cytotoxicity; Decellularized bovine; DNA; Extracellular Matrix - chemistry; glutaraldehyde; heart valves; humans; leaching; Macrophages; Macrophages - cytology; Macrophages - physiology; Materials Testing; metalloproteinases; Pericardium; Pericardium - chemistry; Pericardium - cytology; prostheses; scanning electron microscopy; Tissue Engineering - methods; U937; Crosslinking; Macrophages; Collagen; Decellularized bovine; Pericardium; U937

While macrophages have been implicated in the failure of bioprosthetic heart valves, the macrophage response to crosslinked native pericardial collagen has not been previously investigated. Using decellularized bovine pericardium (DBP) as a model for native collagen, this study investigated the resp...