Species-dependent differences in the biochemical effects and metabolism of 5-benzylacyclouridine

• Published in: Biochemical pharmacology Vol. 45; no. 1; pp. 173 - 181
• Main Authors: Davis, Stephen T., Joyner, Suzanne S., Chandrasurin, Pisal, Baccanari, David P.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 07.01.1993; Elsevier Science
• Subjects: Animals; Antineoplastic agents; Biological and medical sciences; Chemotherapy; Female; Half-Life; Kinetics; Liver - enzymology; Macaca fascicularis; Male; Medical sciences; Mice; Pharmacology. Drug treatments; Rats; Species Specificity; Tissue Extracts - metabolism; Uracil - analogs & derivatives; Uracil - pharmacokinetics; Uridine - blood; Uridine Phosphorylase - antagonists & inhibitors; 5-FU, 5-fluorouracil; LC/MS, liquid chromatography/mass spectrum; 5-FdUrd, 5-fluoro-2'-deoxyuridine; RT, retention time; BAU, 5-benzylacyclouridine, [5-benzyl-1-(2'-hydroxyethoxymethyl)uracil]; BBAU, 5-benzyloxybenzylacyclouridine, [5-( m-benzyloxybenzyl)-1-(2'-hydroxyethoxymethyl)uracil]; UrdPase, uridine phosphorylase; AZT, 3'-azido-3'-deoxythymidine (zidovudine); and T 1 2 , half-life; Antineoplastic agent; Acyclic nucleoside; Intraperitoneal administration; Intravenous administration; Rat; Enzyme; Rodentia; Monkey; Enzyme inhibitor; Species specificity; Metabolism; Vertebrata; Mammalia; Mouse; Uridine phosphorylase; Animal; Primates; Pharmacokinetics; Pyrimidine nucleoside; Uracil

The pharmacokinetics and biochemical effects of the uridine phosphorylase (UrdPase) inhibitor 5-benzylacyclouridine (BAU) were investigated in the mouse, rat and monkey. Following i.p. administration of BAU (30 mg kg ) in the mouse and i.v. administration in the rat and monkey, initial BAU plasma ha...