Radioligand binding affinity and biological activity of the enantiomers of a chiral melatonin analogue

• Published in: European journal of pharmacology Vol. 287; no. 3; pp. 239 - 243
• Main Authors: Sugden, David, Davies, David J., Garratt, Peter J., Jones, Robert, Vonhoff, Stefan
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 20.12.1995; Elsevier
• Subjects: Animals; Binding site; Binding, Competitive; Biological and medical sciences; Brain - metabolism; Carbazoles - administration & dosage; Carbazoles - pharmacology; Chickens; Chiral analog; Circadian Rhythm - drug effects; Hormones. Endocrine system; Iodine Radioisotopes; Lethal Dose 50; Medical sciences; Melanophore, Xenopus laevis; Melanophores - metabolism; Melatonin; Melatonin - analogs & derivatives; Melatonin - pharmacology; Pharmacology. Drug treatments; Pineal Gland - metabolism; Radioligand Assay; Stereoisomerism; Xenopus laevis; Melatonin; Chiral analog; Binding site; Melanophore, Xenopus laevis; Ligand binding; Analog; Carbazole derivatives; Enantiomer; Aminoacid derivative hormone; Melanophore; In vitro; Biological activity; Melatonine; Pineal hormone; Hormonal receptor
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/0014-2999(95)00489-0

Melatonin, a hormone secreted by the pineal gland, can act on the central circadian oscillator in the suprachiasmatic nucleus of the hypothalamus. It has been proposed that melatonin or its analogues may be useful in restoring disturbed circadian rhythms in jet-lag, shift-work and some blind subject...