Molecular Regulation of Circadian Chromatin

• Published in: Journal of molecular biology Vol. 432; no. 12; pp. 3466 - 3482
• Main Authors: Zhu, Qiaoqiao, Belden, William J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 29.05.2020
• Subjects: acetylation; aging; Animals; Chromatin Assembly and Disassembly - genetics; chromatin modifications; chromatin remodeling; circadian clocks; circadian regulation; circadian rhythm; Circadian Rhythm - genetics; Drosophila; Drosophila melanogaster - genetics; Feedback, Physiological; Fungal Proteins - genetics; gene expression; Gene Expression Regulation, Developmental - genetics; genes; genomics; heterochromatin; Heterochromatin - genetics; histone code; histone deacetylase; histones; Histones - genetics; lncRNAs; lysine; methylation; methyltransferases; Methyltransferases - genetics; Mice; Neurospora; Neurospora - genetics; nucleosomes; Repressor Proteins - genetics; RNA, Long Noncoding - genetics; transcription (genetics); lncRNAs; chromatin remodeling; chromatin modifications; aging; circadian regulation

Circadian rhythms are generated by transcriptional negative feedback loops and require histone modifications and chromatin remodeling to ensure appropriate timing and amplitude of clock gene expression. Circadian modifications to histones are important for transcriptional initiation and feedback inh...