Effects of norharman on the mutagenicity of chlorophenylhydroxylamine and its metabolism with rat liver S9

• Published in: Mutation research Vol. 162; no. 2; p. 165
• Main Authors: Suzuki, J, Kobayashi, Y, Monden, S, Suzuki, S
• Format: Journal Article
• Language: English
• Published: Netherlands 01.09.1986
• Subjects: Alkaloids - pharmacology; Animals; Ascorbic Acid - pharmacology; Biotransformation; Carbolines; Cytochrome P-450 Enzyme System - metabolism; Harmine - analogs & derivatives; Harmine - pharmacology; Hydroxylamines - metabolism; Hydroxylamines - toxicity; In Vitro Techniques; Microsomes, Liver - metabolism; Mutagenicity Tests; Mutagens - metabolism; NADP - metabolism; Oxygen - metabolism; Rats; Salmonella typhimurium - drug effects; Salmonella typhimurium - genetics

o,p-Chlorophenylhydroxylamines (CPHAs) (10468-16-3, 823-86-9) only demonstrated mutagenicity in the presence of S9 mix and norharman (NOH) (244-63-3), as well as chloronitrobenzenes. The mutagenic activity of o-CPHA was 30 times higher than that of p-CPHA. When o-CPHA was preincubated with S9 mix wi...