Notch4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areata

• Published in: Human genetics Vol. 112; no. 4; pp. 400 - 403
• Main Authors: Tazi-Ahnini, R., Cork, M. J., Wengraf, D., Wilson, A. G., Gawkrodger, D. J., Birch, M. P., Messenger, A. G., McDonagh, A. J. G.
• Format: Journal Article
• Language: English
• Published: Germany Springer 01.04.2003; Springer Nature B.V
• Subjects: Alleles; Alopecia; Alopecia Areata - diagnosis; Alopecia Areata - genetics; Baldness; Case-Control Studies; Genes; Genetic aspects; Genetic engineering; Genetic polymorphisms; Genetic research; Genotype; Humans; Medical research; Medicine, Experimental; Odds Ratio; Polymorphism, Genetic; Proto-Oncogene Proteins - genetics; Receptor, Notch4; Receptors, Cell Surface; Receptors, Notch; Severity of Illness Index

Alopecia areata (AA) is a disorder primarily affecting the hair and nails in which associated autoimmune or atopic disease is common. Genetically, it is a complex trait with evidence of a role for genes of the major histocompatibility complex (MHC), the interleukin-1 cluster and chromosome 21 in the...