A post-mortem comparison of the cortical cholinergic system in Alzheimer's disease and Pick's disease
Assessment of neurochemical markers in the frontal cortex indicates that choline acetyltransferase is significantly decreased in Alzheimer's and Gerstmann Straussler dementias but not in Pick's dementia. It therefore appears that the cholinergic innervation of the cortex from the basal for...
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| Published in | Journal of the neurological sciences Vol. 62; no. 1; pp. 211 - 217 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Shannon
Elsevier B.V
01.12.1983
Elsevier Science |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Assessment of neurochemical markers in the frontal cortex indicates that choline acetyltransferase is significantly decreased in Alzheimer's and Gerstmann Straussler dementias but not in Pick's dementia. It therefore appears that the cholinergic innervation of the cortex from the basal forebrain is intact in Pick's disease. Cortical somatostatin was decreased only in Alzheimer's disease (AD), indicating that loss of somatostatin is not a constant feature in different forms of dementia. Muscarinic binding sites were unaltered in Pick's disease and Gerstmann-Straussler syndrome but were decreased in a subpopulation of AD patients. These data suggest that in some cases of AD a significant loss of cholinoceptive neurones in the cortex is evident. |
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| AbstractList | Assessment of neurochemical markers in the frontal cortex indicates that choline acetyltransferase is significantly decreased in Alzheimer's and Gerstmann-Straussler dementias but not in Pick's dementia. It therefore appears that the cholinergic innervation of the cortex from the basal forebrain is intact in Pick's disease. Cortical somatostatin was decreased only in Alzheimer's disease (AD), indicating that loss of somatostatin is not a constant feature in different forms of dementia. Muscarinic binding sites were unaltered in Pick's disease and Gerstmann-Straussler syndrome but were decreased in a subpopulation of AD patients. These data suggest that in some cases of AD a significant loss of cholinoceptive neurones in the cortex is evident. |
| Author | Lal, S. Wood, P.L. Haltia, M. Paetau, A. Etienne, P. Nair, N.P.V. Finlayson, M.H. Gauthier, S. Palo, J. Bird, E.D. |
| Author_xml | – sequence: 1 givenname: P.L. surname: Wood fullname: Wood, P.L. organization: Douglas Hospital Research Centre, Verdun, Quebec Canada – sequence: 2 givenname: P. surname: Etienne fullname: Etienne, P. organization: Douglas Hospital Research Centre, Verdun, Quebec Canada – sequence: 3 givenname: S. surname: Lal fullname: Lal, S. organization: Douglas Hospital Research Centre, Verdun, Quebec Canada – sequence: 4 givenname: N.P.V. surname: Nair fullname: Nair, N.P.V. organization: Douglas Hospital Research Centre, Verdun, Quebec Canada – sequence: 5 givenname: M.H. surname: Finlayson fullname: Finlayson, M.H. organization: Montreal General Hospital, Montreal, Quebec Canada – sequence: 6 givenname: S. surname: Gauthier fullname: Gauthier, S. organization: Douglas Hospital Research Centre, Verdun, Quebec Canada – sequence: 7 givenname: J. surname: Palo fullname: Palo, J. organization: Department of Neurology, University of Helsinki, Helsinki Finland – sequence: 8 givenname: M. surname: Haltia fullname: Haltia, M. organization: Department of Pathology, University of Helsinki, Helsinki Finland – sequence: 9 givenname: A. surname: Paetau fullname: Paetau, A. organization: Department of Pathology, University of Helsinki, Helsinki Finland – sequence: 10 givenname: E.D. surname: Bird fullname: Bird, E.D. organization: McLean Hospital, Brain Tissue Resource Centre, Belmont, MA U.S.A |
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| Cites_doi | 10.1016/S0140-6736(76)91936-X 10.1126/science.6803359 10.1016/0304-3940(80)90177-9 10.1097/00005072-197911000-00006 10.1192/bjp.112.483.127 10.1001/archneur.1972.00490080015001 10.1016/S0278-5846(82)80144-9 10.1016/S0021-9258(19)52451-6 10.1016/0197-4580(81)90032-4 10.1002/ana.410100203 10.1001/archneur.1962.04210030065009 10.1038/288279a0 10.1159/000114320 10.1016/0006-8993(77)90758-2 10.1001/archneur.1982.00510170029008 10.1007/BF00684727 10.1038/266558a0 10.1042/bj1150465 10.1016/0024-3205(82)90099-6 10.1016/0022-510X(82)90026-0 10.1093/geronj/37.4.422 10.1093/brain/105.2.313 10.1016/0006-8993(78)90562-0 10.1016/0022-510X(80)90205-1 10.1136/bmj.2.6150.1457 10.1146/annurev.ne.03.030180.000453 10.1016/S0140-6736(77)91780-9 10.1016/S0140-6736(77)92114-6 |
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| Keywords | Pick's disease Choline acetyltransferase Somatostatin Muscarinic receptors Alzheimer's disease Gerstmann-Straussler syndrome Human Cerebral cortex Nervous system diseases Alzheimer disease Autopsy Pick disease Degenerative disease Muscarinic receptor Neuropeptide |
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| References | Torvik (BIB29) 1970; 46 Price, Whitehouse, Struble, Clark, Coyle, DeLong, Hedreen (BIB17) 1982; 1 Reisine, Yamamura, Bird, Spokes, Enna (BIB18) 1978; 159 Spillane, White, Goodhardt, Flack, Bowen, Davison (BIB26) 1977; 266 Hirano, Zimmermann (BIB12) 1962; 7 Wechsler, Verity, Rosenschein, Fried, Scheibel (BIB30) 1982; 39 Rossor, Emson, Mountjoy, Roth, Iversen (BIB20) 1980; 20 Perry, Tomlinson, Blessed, Bergmann, Gibson, Perry (BIB15) 1978; II Ball (BIB1) 1979; 38 Perry, Perry, Blessed, Tomlinson (BIB14) 1977; i Rossor, Garrett, Johnson, Mountjoy, Roth, Iversen (BIB21) 1982; 105 Schochet, Earle (BIB22) 1970; 15 Heston, Mastri (BIB11) 1982; 37 Perry, Blessed, Tomlinson, Perry, Crow, Cross, Dockray, Dimaline, Arregui (BIB16) 1981; 2 Terry, Davies (BIB28) 1980; 3 Struble, Cork, Whitehouse, Price (BIB27) 1982; 216 Yates, Simpson, Maloney, Gordon (BIB36) 1980; 48 Yamamura, Snyder (BIB35) 1974; 71 Whitehouse, Price, Clark, Coyle, DeLong (BIB32) 1981; 10 Lowry, Rosebrough, Farr, Randall (BIB13) 1951; 193 Constantinidis, Richard, Tissot (BIB6) 1974; 11 Davies, Katzman, Terry (BIB9) 1980; 288 White, Hiley, Goodhardt, Carrasco, Keet, Williams, Bowen (BIB31) 1977; i Birdsall, Burgen, Hulme (BIB3) 1978; 14 Fonnum (BIB10) 1969; 115 Wood, Etienne, Lal, Gauthier, Cajal, Nair (BIB34) 1982; 31 Davies, Verth (BIB8) 1977; 138 Bird (BIB2) 1977 Robitaille, Wood, Etienne, Lal, Finlayson, Gauthier, Nair (BIB19) 1982; 6 Smith, Turner, Sim (BIB25) 1966; 112 Seitelberger (BIB23) 1975 Shefer (BIB24) 1972; 72 Bowen, Benton, Spillane, Smith, Allen (BIB4) 1982; 57 Cleland (BIB5) 1967; 29 Davies, Maloney (BIB7) 1976; ii Wisniewski, Coblentz, Terry (BIB33) 1972; 26 Torvik (10.1016/0022-510X(83)90200-9_BIB29) 1970; 46 Struble (10.1016/0022-510X(83)90200-9_BIB27) 1982; 216 Wisniewski (10.1016/0022-510X(83)90200-9_BIB33) 1972; 26 Wood (10.1016/0022-510X(83)90200-9_BIB34) 1982; 31 Davies (10.1016/0022-510X(83)90200-9_BIB8) 1977; 138 Davies (10.1016/0022-510X(83)90200-9_BIB9) 1980; 288 Cleland (10.1016/0022-510X(83)90200-9_BIB5) 1967; 29 Perry (10.1016/0022-510X(83)90200-9_BIB16) 1981; 2 Spillane (10.1016/0022-510X(83)90200-9_BIB26) 1977; 266 Yates (10.1016/0022-510X(83)90200-9_BIB36) 1980; 48 Lowry (10.1016/0022-510X(83)90200-9_BIB13) 1951; 193 White (10.1016/0022-510X(83)90200-9_BIB31) 1977; i Bowen (10.1016/0022-510X(83)90200-9_BIB4) 1982; 57 Whitehouse (10.1016/0022-510X(83)90200-9_BIB32) 1981; 10 Smith (10.1016/0022-510X(83)90200-9_BIB25) 1966; 112 Terry (10.1016/0022-510X(83)90200-9_BIB28) 1980; 3 Perry (10.1016/0022-510X(83)90200-9_BIB14) 1977; i Price (10.1016/0022-510X(83)90200-9_BIB17) 1982; 1 Yamamura (10.1016/0022-510X(83)90200-9_BIB35) 1974; 71 Shefer (10.1016/0022-510X(83)90200-9_BIB24) 1972; 72 Bird (10.1016/0022-510X(83)90200-9_BIB2) 1977 Constantinidis (10.1016/0022-510X(83)90200-9_BIB6) 1974; 11 Davies (10.1016/0022-510X(83)90200-9_BIB7) 1976; ii Seitelberger (10.1016/0022-510X(83)90200-9_BIB23) 1975 Wechsler (10.1016/0022-510X(83)90200-9_BIB30) 1982; 39 Reisine (10.1016/0022-510X(83)90200-9_BIB18) 1978; 159 Ball (10.1016/0022-510X(83)90200-9_BIB1) 1979; 38 Heston (10.1016/0022-510X(83)90200-9_BIB11) 1982; 37 Robitaille (10.1016/0022-510X(83)90200-9_BIB19) 1982; 6 Hirano (10.1016/0022-510X(83)90200-9_BIB12) 1962; 7 Rossor (10.1016/0022-510X(83)90200-9_BIB20) 1980; 20 Schochet (10.1016/0022-510X(83)90200-9_BIB22) 1970; 15 Birdsall (10.1016/0022-510X(83)90200-9_BIB3) 1978; 14 Fonnum (10.1016/0022-510X(83)90200-9_BIB10) 1969; 115 Rossor (10.1016/0022-510X(83)90200-9_BIB21) 1982; 105 Perry (10.1016/0022-510X(83)90200-9_BIB15) 1978; II |
| References_xml | – volume: 14 start-page: 723 year: 1978 end-page: 736 ident: BIB3 article-title: The binding of agonists to brain muscarinic receptors publication-title: Mol. Pharmacol. contributor: fullname: Hulme – volume: 72 start-page: 1024 year: 1972 end-page: 1029 ident: BIB24 article-title: Absolute number of neurons and thickness of the cerebral cortex during aging, senile and vascular dementia and Pick's and Alzheimer's diseases publication-title: Zh. Nevropat. Psikhiat. contributor: fullname: Shefer – volume: 115 start-page: 465 year: 1969 end-page: 472 ident: BIB10 article-title: Radiochemical microassays for the determination of choline acetyltransferase and acetylcholinesterase activities publication-title: Biochem. J. contributor: fullname: Fonnum – volume: 105 start-page: 313 year: 1982 end-page: 330 ident: BIB21 article-title: A post-mortem study of the cholinergic and GABA systems in senile dementia publication-title: Brain contributor: fullname: Iversen – volume: 193 start-page: 265 year: 1951 end-page: 275 ident: BIB13 article-title: Protein measurement with the Folin phenol reagent publication-title: J. Biol. Chem. contributor: fullname: Randall – volume: 3 start-page: 77 year: 1980 end-page: 95 ident: BIB28 article-title: Dementia of the Alzheimer type publication-title: Ann. Rev. Neurosci. contributor: fullname: Davies – volume: 48 start-page: 257 year: 1980 end-page: 263 ident: BIB36 article-title: Neurochemical observations in a case of Pick's disease publication-title: J. Neurol Sci. contributor: fullname: Gordon – volume: 7 start-page: 227 year: 1962 end-page: 242 ident: BIB12 article-title: Alzheimer's neurofibrillary changes — A topographic study publication-title: Arch. Neurol. (Chic.) contributor: fullname: Zimmermann – volume: ii start-page: 1403 year: 1976 ident: BIB7 article-title: Selective loss of central cholinergic neurons in Alzheimer's disease publication-title: Lancet contributor: fullname: Maloney – volume: 159 start-page: 477 year: 1978 end-page: 481 ident: BIB18 article-title: Pre- and postsynaptic neurochemical alterations in Alzheimer's disease publication-title: Brain Res. contributor: fullname: Enna – volume: 138 start-page: 385 year: 1977 end-page: 392 ident: BIB8 article-title: Regional distribution of muscarinic acetylcholine receptor in normal and Alzheimer's type dementia brains publication-title: Brain Res. contributor: fullname: Verth – volume: 2 start-page: 251 year: 1981 end-page: 256 ident: BIB16 article-title: Neurochemical activities in human temporal lobe related to aging and Alzheimer-type changes publication-title: Neurobiol. Aging contributor: fullname: Arregui – volume: 1 start-page: 84 year: 1982 end-page: 92 ident: BIB17 article-title: Basal forebrain cholinergic systems in Alzheimer's disease and related dementias publication-title: Neuroscience Commentaries contributor: fullname: Hedreen – volume: 266 start-page: 558 year: 1977 end-page: 559 ident: BIB26 article-title: Selective vulnerability of neurones in organic dementia publication-title: Nature (Lond.) contributor: fullname: Davison – volume: i start-page: 189 year: 1977 ident: BIB14 article-title: Micropsy evidence of central cholinergic deficits in senile dementia publication-title: Lancet contributor: fullname: Tomlinson – volume: 31 start-page: 2073 year: 1982 end-page: 2079 ident: BIB34 article-title: Reduced lumbar CSF somatostatin levels in Alzheimer's disease publication-title: Life Sci. contributor: fullname: Nair – volume: 15 start-page: 293 year: 1970 end-page: 297 ident: BIB22 article-title: Pick's disease with compound intraneuronal inclusion bodies publication-title: Acta Neuropath. (Berl.) contributor: fullname: Earle – volume: 112 start-page: 127 year: 1966 end-page: 133 ident: BIB25 article-title: Cerebral biopsy in the investigation of presenile dementia, Part 2 (Pathological aspects) publication-title: Brit. J. Psychiat. contributor: fullname: Sim – start-page: 140 year: 1977 end-page: 149 ident: BIB2 article-title: The clinical significance of disturbances in the central GABA system publication-title: Neurotransmission and Disturbed Behavior contributor: fullname: Bird – start-page: 43 year: 1975 end-page: 71 ident: BIB23 article-title: General neuropathology of the degenerative diseases of the central nervous system publication-title: Handbook of Clinical Neurology, Vol. 21, Part I (System Disorders and Atrophies) contributor: fullname: Seitelberger – volume: 39 start-page: 287 year: 1982 end-page: 290 ident: BIB30 article-title: Pick's disease — A clinical computed tomographic and histologic study with Golgi impregnation observations publication-title: Arch. Neurol. (Chic.) contributor: fullname: Scheibel – volume: 38 start-page: 614 year: 1979 end-page: 620 ident: BIB1 article-title: Topography of Pick inclusion bodies in hippocampi of demented patients — A quantitative study publication-title: J. Neuropath. Exp. Neurol. contributor: fullname: Ball – volume: 288 start-page: 279 year: 1980 end-page: 280 ident: BIB9 article-title: Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementia publication-title: Nature (Lond.) contributor: fullname: Terry – volume: 6 start-page: 529 year: 1982 end-page: 531 ident: BIB19 article-title: Reduced cortical choline acetyltransferase activity in Gerstmann-Straussler syndrome publication-title: Progr. Neuro-Psychopharmacol. Biol. Psychiat. contributor: fullname: Nair – volume: i start-page: 668 year: 1977 end-page: 671 ident: BIB31 article-title: Neocortical cholinergic neurons in elderly people publication-title: Lancet contributor: fullname: Bowen – volume: 10 start-page: 122 year: 1981 end-page: 126 ident: BIB32 article-title: Alzheimer's disease Evidence for selective loss of cholinergic neurons in the nucleus basalis publication-title: Ann. Neurol. contributor: fullname: DeLong – volume: 11 start-page: 208 year: 1974 end-page: 217 ident: BIB6 article-title: Pick's disease — Histological and clinical correlations publication-title: Europ. Neurol. contributor: fullname: Tissot – volume: 26 start-page: 97 year: 1972 end-page: 108 ident: BIB33 article-title: Pick's disease — A clinical and ultrastructural study publication-title: Arch. Neurol. (Chic.) contributor: fullname: Terry – volume: II start-page: 1457 year: 1978 end-page: 1459 ident: BIB15 article-title: Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia publication-title: Brit. Med. J. contributor: fullname: Perry – volume: 29 start-page: 1 year: 1967 end-page: 32 ident: BIB5 article-title: The statistical analysis of enzyme kinetic data publication-title: Adv. Enzym. contributor: fullname: Cleland – volume: 20 start-page: 373 year: 1980 end-page: 377 ident: BIB20 article-title: Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of the Alzheimer type publication-title: Neurosci. Lett. contributor: fullname: Iversen – volume: 46 start-page: 19 year: 1970 end-page: 31 ident: BIB29 article-title: Aspects of the pathology of presenile dementia publication-title: Acta Neurol. Scand. contributor: fullname: Torvik – volume: 216 start-page: 413 year: 1982 end-page: 415 ident: BIB27 article-title: Cholinergic innervation in neuritic plaques publication-title: Science contributor: fullname: Price – volume: 71 start-page: 1725 year: 1974 end-page: 1729 ident: BIB35 article-title: Muscarinic cholinergic binding in rat brain publication-title: Proc. Nat. Acad. Sci (USA) contributor: fullname: Snyder – volume: 57 start-page: 191 year: 1982 end-page: 202 ident: BIB4 article-title: Choline acetyltransferase activity and histopathology of frontal neocortex from biopsies of demented patients publication-title: J. Neurol. Sci. contributor: fullname: Allen – volume: 37 start-page: 422 year: 1982 end-page: 424 ident: BIB11 article-title: Age at onset of Pick's and Alzheimer's dementia — Implications for diagnosis and research publication-title: J. Geront. contributor: fullname: Mastri – volume: ii start-page: 1403 year: 1976 ident: 10.1016/0022-510X(83)90200-9_BIB7 article-title: Selective loss of central cholinergic neurons in Alzheimer's disease publication-title: Lancet doi: 10.1016/S0140-6736(76)91936-X contributor: fullname: Davies – volume: 216 start-page: 413 year: 1982 ident: 10.1016/0022-510X(83)90200-9_BIB27 article-title: Cholinergic innervation in neuritic plaques publication-title: Science doi: 10.1126/science.6803359 contributor: fullname: Struble – volume: 20 start-page: 373 year: 1980 ident: 10.1016/0022-510X(83)90200-9_BIB20 article-title: Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of the Alzheimer type publication-title: Neurosci. Lett. doi: 10.1016/0304-3940(80)90177-9 contributor: fullname: Rossor – volume: 71 start-page: 1725 year: 1974 ident: 10.1016/0022-510X(83)90200-9_BIB35 article-title: Muscarinic cholinergic binding in rat brain contributor: fullname: Yamamura – volume: 38 start-page: 614 year: 1979 ident: 10.1016/0022-510X(83)90200-9_BIB1 article-title: Topography of Pick inclusion bodies in hippocampi of demented patients — A quantitative study publication-title: J. Neuropath. Exp. Neurol. doi: 10.1097/00005072-197911000-00006 contributor: fullname: Ball – volume: 112 start-page: 127 year: 1966 ident: 10.1016/0022-510X(83)90200-9_BIB25 article-title: Cerebral biopsy in the investigation of presenile dementia, Part 2 (Pathological aspects) publication-title: Brit. J. Psychiat. doi: 10.1192/bjp.112.483.127 contributor: fullname: Smith – volume: 26 start-page: 97 year: 1972 ident: 10.1016/0022-510X(83)90200-9_BIB33 article-title: Pick's disease — A clinical and ultrastructural study publication-title: Arch. Neurol. (Chic.) doi: 10.1001/archneur.1972.00490080015001 contributor: fullname: Wisniewski – volume: 29 start-page: 1 year: 1967 ident: 10.1016/0022-510X(83)90200-9_BIB5 article-title: The statistical analysis of enzyme kinetic data publication-title: Adv. Enzym. contributor: fullname: Cleland – volume: 6 start-page: 529 year: 1982 ident: 10.1016/0022-510X(83)90200-9_BIB19 article-title: Reduced cortical choline acetyltransferase activity in Gerstmann-Straussler syndrome publication-title: Progr. Neuro-Psychopharmacol. Biol. Psychiat. doi: 10.1016/S0278-5846(82)80144-9 contributor: fullname: Robitaille – volume: 193 start-page: 265 year: 1951 ident: 10.1016/0022-510X(83)90200-9_BIB13 article-title: Protein measurement with the Folin phenol reagent publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)52451-6 contributor: fullname: Lowry – volume: 2 start-page: 251 year: 1981 ident: 10.1016/0022-510X(83)90200-9_BIB16 article-title: Neurochemical activities in human temporal lobe related to aging and Alzheimer-type changes publication-title: Neurobiol. Aging doi: 10.1016/0197-4580(81)90032-4 contributor: fullname: Perry – volume: 72 start-page: 1024 year: 1972 ident: 10.1016/0022-510X(83)90200-9_BIB24 article-title: Absolute number of neurons and thickness of the cerebral cortex during aging, senile and vascular dementia and Pick's and Alzheimer's diseases publication-title: Zh. Nevropat. Psikhiat. contributor: fullname: Shefer – volume: 46 start-page: 19 issue: Suppl. 43 year: 1970 ident: 10.1016/0022-510X(83)90200-9_BIB29 article-title: Aspects of the pathology of presenile dementia publication-title: Acta Neurol. Scand. contributor: fullname: Torvik – volume: 10 start-page: 122 year: 1981 ident: 10.1016/0022-510X(83)90200-9_BIB32 article-title: Alzheimer's disease Evidence for selective loss of cholinergic neurons in the nucleus basalis publication-title: Ann. Neurol. doi: 10.1002/ana.410100203 contributor: fullname: Whitehouse – volume: 7 start-page: 227 year: 1962 ident: 10.1016/0022-510X(83)90200-9_BIB12 article-title: Alzheimer's neurofibrillary changes — A topographic study publication-title: Arch. Neurol. (Chic.) doi: 10.1001/archneur.1962.04210030065009 contributor: fullname: Hirano – start-page: 43 year: 1975 ident: 10.1016/0022-510X(83)90200-9_BIB23 article-title: General neuropathology of the degenerative diseases of the central nervous system contributor: fullname: Seitelberger – volume: 288 start-page: 279 year: 1980 ident: 10.1016/0022-510X(83)90200-9_BIB9 article-title: Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementia publication-title: Nature (Lond.) doi: 10.1038/288279a0 contributor: fullname: Davies – volume: 11 start-page: 208 year: 1974 ident: 10.1016/0022-510X(83)90200-9_BIB6 article-title: Pick's disease — Histological and clinical correlations publication-title: Europ. Neurol. doi: 10.1159/000114320 contributor: fullname: Constantinidis – volume: 138 start-page: 385 year: 1977 ident: 10.1016/0022-510X(83)90200-9_BIB8 article-title: Regional distribution of muscarinic acetylcholine receptor in normal and Alzheimer's type dementia brains publication-title: Brain Res. doi: 10.1016/0006-8993(77)90758-2 contributor: fullname: Davies – volume: 39 start-page: 287 year: 1982 ident: 10.1016/0022-510X(83)90200-9_BIB30 article-title: Pick's disease — A clinical computed tomographic and histologic study with Golgi impregnation observations publication-title: Arch. Neurol. (Chic.) doi: 10.1001/archneur.1982.00510170029008 contributor: fullname: Wechsler – volume: 15 start-page: 293 year: 1970 ident: 10.1016/0022-510X(83)90200-9_BIB22 article-title: Pick's disease with compound intraneuronal inclusion bodies publication-title: Acta Neuropath. (Berl.) doi: 10.1007/BF00684727 contributor: fullname: Schochet – volume: 266 start-page: 558 year: 1977 ident: 10.1016/0022-510X(83)90200-9_BIB26 article-title: Selective vulnerability of neurones in organic dementia publication-title: Nature (Lond.) doi: 10.1038/266558a0 contributor: fullname: Spillane – start-page: 140 year: 1977 ident: 10.1016/0022-510X(83)90200-9_BIB2 article-title: The clinical significance of disturbances in the central GABA system contributor: fullname: Bird – volume: 115 start-page: 465 year: 1969 ident: 10.1016/0022-510X(83)90200-9_BIB10 article-title: Radiochemical microassays for the determination of choline acetyltransferase and acetylcholinesterase activities publication-title: Biochem. J. doi: 10.1042/bj1150465 contributor: fullname: Fonnum – volume: 31 start-page: 2073 year: 1982 ident: 10.1016/0022-510X(83)90200-9_BIB34 article-title: Reduced lumbar CSF somatostatin levels in Alzheimer's disease publication-title: Life Sci. doi: 10.1016/0024-3205(82)90099-6 contributor: fullname: Wood – volume: 57 start-page: 191 year: 1982 ident: 10.1016/0022-510X(83)90200-9_BIB4 article-title: Choline acetyltransferase activity and histopathology of frontal neocortex from biopsies of demented patients publication-title: J. Neurol. Sci. doi: 10.1016/0022-510X(82)90026-0 contributor: fullname: Bowen – volume: 14 start-page: 723 year: 1978 ident: 10.1016/0022-510X(83)90200-9_BIB3 article-title: The binding of agonists to brain muscarinic receptors publication-title: Mol. Pharmacol. contributor: fullname: Birdsall – volume: 37 start-page: 422 year: 1982 ident: 10.1016/0022-510X(83)90200-9_BIB11 article-title: Age at onset of Pick's and Alzheimer's dementia — Implications for diagnosis and research publication-title: J. Geront. doi: 10.1093/geronj/37.4.422 contributor: fullname: Heston – volume: 1 start-page: 84 year: 1982 ident: 10.1016/0022-510X(83)90200-9_BIB17 article-title: Basal forebrain cholinergic systems in Alzheimer's disease and related dementias publication-title: Neuroscience Commentaries contributor: fullname: Price – volume: 105 start-page: 313 year: 1982 ident: 10.1016/0022-510X(83)90200-9_BIB21 article-title: A post-mortem study of the cholinergic and GABA systems in senile dementia publication-title: Brain doi: 10.1093/brain/105.2.313 contributor: fullname: Rossor – volume: 159 start-page: 477 year: 1978 ident: 10.1016/0022-510X(83)90200-9_BIB18 article-title: Pre- and postsynaptic neurochemical alterations in Alzheimer's disease publication-title: Brain Res. doi: 10.1016/0006-8993(78)90562-0 contributor: fullname: Reisine – volume: 48 start-page: 257 year: 1980 ident: 10.1016/0022-510X(83)90200-9_BIB36 article-title: Neurochemical observations in a case of Pick's disease publication-title: J. Neurol Sci. doi: 10.1016/0022-510X(80)90205-1 contributor: fullname: Yates – volume: II start-page: 1457 year: 1978 ident: 10.1016/0022-510X(83)90200-9_BIB15 article-title: Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia publication-title: Brit. Med. J. doi: 10.1136/bmj.2.6150.1457 contributor: fullname: Perry – volume: 3 start-page: 77 year: 1980 ident: 10.1016/0022-510X(83)90200-9_BIB28 article-title: Dementia of the Alzheimer type publication-title: Ann. Rev. Neurosci. doi: 10.1146/annurev.ne.03.030180.000453 contributor: fullname: Terry – volume: i start-page: 189 year: 1977 ident: 10.1016/0022-510X(83)90200-9_BIB14 article-title: Micropsy evidence of central cholinergic deficits in senile dementia publication-title: Lancet doi: 10.1016/S0140-6736(77)91780-9 contributor: fullname: Perry – volume: i start-page: 668 year: 1977 ident: 10.1016/0022-510X(83)90200-9_BIB31 article-title: Neocortical cholinergic neurons in elderly people publication-title: Lancet doi: 10.1016/S0140-6736(77)92114-6 contributor: fullname: White |
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| SubjectTerms | Adult Aged Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Biological and medical sciences Cerebral Cortex - metabolism Cerebral Cortex - pathology Choline acetyltransferase Choline O-Acetyltransferase - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia - metabolism Dementia - pathology Female Gerstmann-Straussler syndrome Humans Male Medical sciences Middle Aged Muscarinic receptors Neurology Oxotremorine - metabolism Pick's disease Quinuclidinyl Benzilate - metabolism Receptors, Muscarinic - metabolism Somatostatin Somatostatin - metabolism |
| Title | A post-mortem comparison of the cortical cholinergic system in Alzheimer's disease and Pick's disease |
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